ReviewJournal of molecular medicine (Berlin, Germany)2011
Nickel allergies: paying the Toll for innate immunity.
Review in Journal of molecular medicine (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 87 citations in OpenAlex.
- Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy.Allergy · 2026Article
- Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.Contact dermatitis · 2026Article
- Updates in Metal Allergy: A Review of New Pathways of Sensitization, Exposure, and Treatment.Current allergy and asthma reports · 2025Review
- Nickel removal from synthetic wastewater by novel zeolite-doped magnesium- iron- and zinc-oxide nanocomposites by hydrothermal-calcination technique.Scientific reports · 2024Article
- Ion-Imprinted Chitosan-Based Localized Surface Plasmon Resonance Sensor for NiSensors (Basel, Switzerland) · 2022Article
- Curcumin Hybrid Lipid Polymeric Nanoparticles: Antioxidant Activity, Immune Cellular Response, and Cytotoxicity Evaluation.Biomedicines · 2022Article
- Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa.Contact dermatitis · 2020Article
- Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals.PloS one · 2018Article
- Article
- The Many Faces of Graphene as Protection Barrier. Performance under Microbial Corrosion and Ni Allergy Conditions.Materials (Basel, Switzerland) · 2017Article
- Immunoproteomic identification and characterization of NiCell death & disease · 2017Article
- Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development.Frontiers in immunology · 2017Review
- Promotion of Nickel (Ni) Allergy by Anamnestic Sensitization with a Bacterial Component, Lipopolysaccharide (LPS), in Mice.The open dentistry journal · 2016Article
- Interaction of Materials and Biology in Total Joint Replacement - Successes, Challenges and Future Directions.Journal of materials chemistry. B · 2014Article
- Analysis of the toll-like receptor 2-2 (TLR2-2) and TLR4 mRNA expression in the intestinal mucosal immunity of broilers fed on diets supplemented with nickel chloride.International journal of environmental research and public health · 2014Article
- Innate immune reactions in septic and aseptic osteolysis around hip implants.Journal of long-term effects of medical implants · 2014Article
- Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2.EMBO reports · 2012Article
- Nickel-free stainless steel avoids neointima formation following coronary stent implantation.Science and technology of advanced materials · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic contact hypersensitivity responses to the transition metal nickel (Ni(2+)) affect millions of people worldwide despite extensive legislatory efforts to ban the use of Ni(2+) in products coming into direct contact with the skin. Like other contact allergens, Ni(2+) triggers a T lymphocyte-driven delayed-type hypersensitivity reaction that is characterized by leukocyte infiltration at sites of allergen exposure. The last years have revealed that besides a hapten-specific T cell response, Ni(2+) can also directly trigger an innate immune response in resident skin cells that is necessary for mounting an allergic hypersensitivity reaction to Ni(2+). Recently, the receptor for the bacterial membrane component lipopolysaccharide, Toll-like receptor 4, has been identified as the crucial mediator of the innate immune response to Ni(2+), demonstrating that Ni(2+) employs signaling components of the bacterial defense system to elicit its allergic reactions. Here, we provide an overview of Ni(2+)-induced signaling events that have been implicated in contributing to the hypersensitivity response to this transition metal. We briefly review the causes and genetic predisposition fostering allergic responses to Ni(2+) and discuss potential therapeutic and prophylactic strategies and chances evolving from the novel insights into the molecular basis of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.