ArticleChromosoma2011
An intranucleolar body associated with rDNA.
Article in Chromosoma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Immunocytochemical detection of proteins within cellular structures inaccessible to specific antibodies.Histochemistry and cell biology · 2025Review
- The Role of rDNA Clusters in Global Epigenetic Gene Regulation.Frontiers in genetics · 2021Review
- Ribosomal DNA and the Nucleolus as Keystones of Nuclear Architecture, Organization, and Function.Trends in genetics : TIG · 2019Review
- Phase-to-Phase With Nucleoli - Stress Responses, Protein Aggregation and Novel Roles of RNA.Frontiers in cellular neuroscience · 2019Review
- Stress-Induced Low Complexity RNA Activates Physiological Amyloidogenesis.Cell reports · 2018Article
- Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response.Nature communications · 2018Article
- Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.Oncogene · 2018Review
- Review
- Article
- Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways.Histochemistry and cell biology · 2016Review
- Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells.Journal of virology · 2016Article
- New insights into nucleolar structure and function.F1000prime reports · 2015Review
- Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity.Nucleus (Austin, Tex.) · 2015Article
- Functional ultrastructure of the plant nucleolus.Protoplasma · 2014Review
- Probing the stiffness of isolated nucleoli by atomic force microscopy.Histochemistry and cell biology · 2014Article
- A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.Journal of cell science · 2014Article
- Environmental cues induce a long noncoding RNA-dependent remodeling of the nucleolus.Molecular biology of the cell · 2013Article
- Composition and dynamics of the nucleolinus, a link between the nucleolus and cell division apparatus in surf clam (Spisula) oocytes.The Journal of biological chemistry · 2012Article
- A simple method for the immunocytochemical detection of proteins inside nuclear structures that are inaccessible to specific antibodies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- A cell cycle role for the epigenetic factor CTCF-L/BORIS.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
The nucleolus is the subnuclear organelle responsible for ribosome subunit biogenesis and can also act as a stress sensor. It forms around clusters of ribosomal DNA (rDNA) and is mainly organised in three subcompartments, i.e. fibrillar centre, dense fibrillar component and granular component. Here, we describe the localisation of 21 protein factors to an intranucleolar region different to these main subcompartments, called the intranucleolar body (INB). These factors include proteins involved in DNA maintenance, protein turnover, RNA metabolism, chromatin organisation and the post-translational modifiers SUMO1 and SUMO2/3. Increase in the size and number of INBs is promoted by specific types of DNA damage and depends on the functional integrity of the nucleolus. INBs are abundant in nucleoli of unstressed cells during S phase and localise in close proximity to rDNA with heterochromatic features. The data suggest the INB is linked with regulation of rDNA transcription and/or maintenance of rDNA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.