ArticlePloS one2011
Collective dynamics of gene expression in cell populations.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Metabolic cost of rapid adaptation of single yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation.Biology direct · 2015Article
- Single-cell protein dynamics reproduce universal fluctuations in cell populations.The European physical journal. E, Soft matter · 2015Article
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- Article
- Population dynamics of metastable growth-rate phenotypes.PloS one · 2013Article
- Robustness of a rhythmic circuit to short- and long-term temperature changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Metabolic variability in micro-populations.PloS one · 2012Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotypic state of the cell is commonly thought to be determined by the set of expressed genes. However, given the apparent complexity of genetic networks, it remains open what processes stabilize a particular phenotypic state. Moreover, it is not clear how unique is the mapping between the vector of expressed genes and the cell's phenotypic state. To gain insight on these issues, we study here the expression dynamics of metabolically essential genes in twin cell populations. We show that two yeast cell populations derived from a single steady-state mother population and exhibiting a similar growth phenotype in response to an environmental challenge, displayed diverse expression patterns of essential genes. The observed diversity in the mean expression between populations could not result from stochastic cell-to-cell variability, which would be averaged out in our large cell populations. Remarkably, within a population, sets of expressed genes exhibited coherent dynamics over many generations. Thus, the emerging gene expression patterns resulted from collective population dynamics. It suggests that in a wide range of biological contexts, gene expression reflects a self-organization process coupled to population-environment dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.