ArticlePloS one2011
The relationship between asthma and depression in primary care patients: a historical cohort and nested case control study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Behavioural activation therapy for depression in adults with non-communicable diseases.The Cochrane database of systematic reviews · 2020Pooled it
- Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management.American journal of respiratory and critical care medicine · 2020Pooled it
- The Relationship between Depression and Asthma: A Meta-Analysis of Prospective Studies.PloS one · 2015Pooled it
- Impact of interventions targeting anxiety and depression in adults with asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Trial
- Depressive Symptoms Among Urban Adolescents with Asthma: A Focus for Providers.Academic pediatrics · 2019Trial
- Factors associated with having uncontrolled asthma in rural Appalachia.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024Article
- Impact of genetic, sociodemographic, and clinical features on antidepressant treatment trajectories in the perinatal period.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024Article
- Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice.Journal of neuroinflammation · 2022Article
- Decreased Health-Seeking Behaviors in People With Depressive Symptoms: The Korea National Health and Nutrition Examination Survey 2014, 2016, and 2018.Psychiatry investigation · 2022Article
- Social and physical factors related to depression in the older population of Siberia, Russia: a cross-sectional study.BMC geriatrics · 2021Article
- Chronic cough, not asthma, is associated with depression in the elderly: a community-based population analysis in South Korea.The Korean journal of internal medicine · 2019Article
- A Cluster Analysis of Bronchial Asthma Patients with Depressive Symptoms.Internal medicine (Tokyo, Japan) · 2018Article
- Chronic respiratory disease and high altitude are associated with depressive symptoms in four diverse settings.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2016Article
- Psychosomatic treatment for allergic diseases.BioPsychoSocial medicine · 2015Article
- Predictors of perceived asthma control among patients managed in primary care clinics.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Examining the relationship between depression and asthma exacerbations in a prospective follow-up study.Psychosomatic medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesAsthma and depression are common health problems in primary care. Evidence of a relationship between asthma and depression is conflicting.
objectivesto determine 1. The incidence rate and incidence rate ratio of depression in primary care patients with asthma compared to those without asthma, and 2. The standardized mortality ratio of depressed compared to non-depressed patients with asthma.
methodsA historical cohort and nested case control study using data derived from the United Kingdom General Practice Research Database.
participants11,275 incident cases of asthma recorded between 1/1/95 and 31/12/96 age, sex and practice matched with non-cases from the database (ratio 1:1) and followed up through the database for 10 years. 1,660 cases were matched by date of asthma diagnosis with 1,660 controls.
main outcome measuresnumber of cases diagnosed with depression, the number of deaths over the study period.
resultsThe rate of depression in patients with asthma was 22.4/1,000 person years and without asthma 13.8 /1,000 person years. The incident rate ratio (adjusted for age, sex, practice, diabetes, cardiovascular disease, cerebrovascular disease, smoking) was 1.59 (95% CI 1.48-1.71). The increased rate of depression was not associated with asthma severity or oral corticosteroid use. It was associated with the number of consultations (odds ratio per visit 1.09; 95% CI 1.07-1.11). The age and sex adjusted standardized mortality ratio for depressed patients with asthma was 1.87 (95% CI: 1.54-2.27).
conclusionsAsthma is associated with depression. This was not related to asthma severity or oral corticosteroid use but was related to service use. This suggests that a diagnosis of depression is related to health seeking behavior in patients with asthma. There is an increased mortality rate in depressed patients with asthma. The cause of this needs further exploration. Consideration should be given to case-finding for depression in this population.
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