ArticlePloS one2011
Generation of human female reproductive tract epithelium from human embryonic stem cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models.Molecular human reproduction · 2026Review
- Bi-potential hPSC-derived Müllerian duct-like cells for full-thickness and functional endometrium regeneration.NPJ Regenerative medicine · 2022Article
- Peptidome analysis of human intrauterine adhesion tissues and the identification of antifibrotic peptide.Journal of biomedical research · 2022Article
- Endometrial membrane organoids from human embryonic stem cell combined with the 3D Matrigel for endometrium regeneration in asherman syndrome.Bioactive materials · 2021Article
- Building a stem cell-based primate uterus.Communications biology · 2021Review
- Bioengineering of the Uterus.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Regenerative Medicine Approaches in Bioengineering Female Reproductive Tissues.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- An update on stem cell therapy for Asherman syndrome.Journal of assisted reproduction and genetics · 2020Review
- Microphysiological Modeling of the Human Endometrium.Tissue engineering. Part A · 2020Article
- Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway.Stem cell reports · 2018Article
- Comparison of Teratoma Formation between Embryonic Stem Cells and Parthenogenetic Embryonic Stem Cells by Molecular Imaging.Stem cells international · 2018Article
- Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.Scientific reports · 2017Article
- Differentiating mouse embryonic stem cells express markers of human endometrium.Reproductive biology and endocrinology : RB&E · 2017Article
- Article
- Prospects for regenerative medicine approaches in women's health.Journal of anatomy · 2015Review
- Upregulation HOXA10 homeobox gene in endometrial cancer: role in cell cycle regulation.Medical oncology (Northwood, London, England) · 2014Article
- In vitro differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mouse: a proteomic analysis.International journal of clinical and experimental pathology · 2014Article
- Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis.Obstetrics and gynecology international · 2013Article
- Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment.Stem cell research & therapy · 2013Review
- Endometrial regeneration and endometrial stem/progenitor cells.Reviews in endocrine & metabolic disorders · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have identified stem/progenitor cells in human and mouse uterine epithelium, which are postulated to be responsible for tissue regeneration and proliferative disorders of human endometrium. These progenitor cells are thought to be derived from Müllerian duct (MD), the primordial female reproductive tract (FRT). METHODOLOGY/PRINCIPAL
findingsWe have developed a model of human reproductive tract development in which inductive neonatal mouse uterine mesenchyme (nMUM) is recombined with green fluorescent protein (GFP)-tagged human embryonic stem cells (hESCs); GFP-hESC (ENVY). We demonstrate for the first time that hESCs can be differentiated into cells with a human FRT epithelial cell phenotype. hESC derived FRT epithelial cells emerged from cultures containing MIXL1(+) mesendodermal precursors, paralleling events occurring during normal organogenesis. Following transplantation, nMUM treated embryoid bodies (EBs) generated epithelial structures with a typical MD phenotype that expressed the MD markers PAX2, HOXA10. Functionally, the hESCs derived FRT epithelium responded to exogenous estrogen by proliferating and secreting uterine-specific glycodelin A (GdA). CONCLUSIONS/SIGNIFICANCE: These data show nMUM can induce differentiation of hESC to form the FRT epithelium. This may provide a model to study early developmental events of the human FRT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.