ArticlePloS one2011
Fractal characteristics of May-Grünwald-Giemsa stained chromatin are independent prognostic factors for survival in multiple myeloma.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 61 citations in OpenAlex.
- The Fractal Viewpoint of Tumors and Nanoparticles.Current medicinal chemistry · 2023Review
- Morphological, fractal, and textural features for the blood cell classification: the case of acute myeloid leukemia.European biophysics journal : EBJ · 2021Article
- A simple score derived from bone marrow immunophenotyping is important for prognostic evaluation in myelodysplastic syndromes.Scientific reports · 2020Observational
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- Classification of Partial Discharge Measured under Different Levels of Noise Contamination.PloS one · 2017Article
- Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.Scientific reports · 2016Article
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- Risk Stratification in Multiple Myeloma.Current hematologic malignancy reports · 2016Review
- A New Image Analysis Method Based on Morphometric and Fractal Parameters for Rapid Evaluation of In Situ Mammalian Mast Cell Status.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2015Article
- Lung cancer-a fractal viewpoint.Nature reviews. Clinical oncology · 2015Review
- Low educational level but not low income impairs the achievement of cytogenetic remission in chronic myeloid leukemia patients treated with imatinib in Brazil.Clinics (Sao Paulo, Brazil) · 2015Article
- Sub-Classification of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma by Pathologic Criteria.PloS one · 2015Article
- Prognostic influence of pre-operative C-reactive protein in node-negative breast cancer patients.PloS one · 2014Article
- Article
- Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis.Expert review of molecular diagnostics · 2013Review
- Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells.Cell proliferation · 2013Article
- Fractal analysis of elastographic images for automatic detection of diffuse diseases of salivary glands: preliminary results.Computational and mathematical methods in medicine · 2013Article
- Immunophenotyping in myelodysplastic syndromes can add prognostic information to well-established and new clinical scores.PloS one · 2013Article
- Molecular characteristics and chromatin texture features in acute promyelocytic leukemia.Diagnostic pathology · 2012Article
- Sequence Complexity of Chromosome 3 in Caenorhabditis elegans.Advances in bioinformatics · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of computerized image analysis for the study of nuclear texture features has provided important prognostic information for several neoplasias. Recently fractal characteristics of the chromatin structure in routinely stained smears have shown to be independent prognostic factors in acute leukemia. In the present study we investigated the influence of the fractal dimension (FD) of chromatin on survival of patients with multiple myeloma. METHODOLOGY: We analyzed 67 newly diagnosed patients from our Institution treated in the Brazilian Multiple Myeloma Study Group. Diagnostic work-up consisted of peripheral blood counts, bone marrow cytology, bone radiograms, serum biochemistry and cytogenetics. The International Staging System (ISS) was used. In every patient, at least 40 digital nuclear images from diagnostic May-Grünwald-Giemsa stained bone marrow smears were acquired and transformed into pseudo-3D images. FD was determined by the Minkowski-Bouligand method extended to three dimensions. Goodness-of-fit of FD was estimated by the R(2) values in the log-log plots. The influence of diagnostic features on overall survival was analyzed in Cox regressions. Patients that underwent autologous bone marrow transplantation were censored at the day of transplantation. PRINCIPAL
findingsMedian age was 56 years. According to ISS, 14% of the patients were stage I, 39% were stage II and 47% were stage III. Additional features of a bad prognosis were observed in 46% of the cases. When stratifying for ISS, both FD and its goodness-of-fit were significant prognostic factors in univariate analyses. Patients with higher FD values or lower goodness-of-fit showed a worse outcome. In the multivariate Cox-regression, FD, R(2), and ISS stage entered the final model, which showed to be stable in a bootstrap resampling study.
conclusionsFractal characteristics of the chromatin texture in routine cytological preparations revealed relevant prognostic information in patients with multiple myeloma.
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