ArticlePloS one2011
Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Cefpiramide RestrictsACS medicinal chemistry letters · 2026Article
- Article
- In-silico development of a novel TLR2-mediating multi-epitope vaccine againstIn silico pharmacology · 2025Article
- A Role forInternational journal of molecular sciences · 2021Article
- RegX3-Mediated Regulation of Methylcitrate Cycle inFrontiers in microbiology · 2021Article
- RegX3 ActivatesFrontiers in microbiology · 2020Article
- Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?Frontiers in cellular and infection microbiology · 2020Review
- Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.Pathogens and disease · 2018Article
- Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery.Pathogens (Basel, Switzerland) · 2018Review
- A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.ACS infectious diseases · 2016Article
- The emerging role of gasotransmitters in the pathogenesis of tuberculosis.Nitric oxide : biology and chemistry · 2016Review
- Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection.Scientific reports · 2016Article
- Imaging the NADH:NADFrontiers in cellular and infection microbiology · 2016Article
- Virulence factor SenX3 is the oxygen-controlled replication switch of Mycobacterium tuberculosis.Antioxidants & redox signaling · 2015Article
- Article
- Hypoxia-activated cytochrome bd expression in Mycobacterium smegmatis is cyclic AMP receptor protein dependent.Journal of bacteriology · 2014Article
- Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria.Microbiology spectrum · 2014Review
- Genomic variations associated with attenuation in Mycobacterium avium subsp. paratuberculosis vaccine strains.BMC microbiology · 2013Article
- Virulence factors of the Mycobacterium tuberculosis complex.Virulence · 2013Review
- ald of Mycobacterium tuberculosis encodes both the alanine dehydrogenase and the putative glycine dehydrogenase.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Two component regulatory systems are used widely by bacteria to coordinate changes in global gene expression profiles in response to environmental signals. The SenX3-RegX3 two component system of Mycobacterium tuberculosis has previously been shown to play a role in virulence and phosphate-responsive control of gene expression. We demonstrate that expression of SenX3-RegX3 is controlled in response to growth conditions, although the absolute changes are small. Global gene expression profiling of a RegX3 deletion strain and wild-type strain in different culture conditions (static, microaerobic, anaerobic), as well as in an over-expressing strain identified a number of genes with changed expression patterns. Among those were genes previously identified as differentially regulated in aerobic culture, including ald (encoding alanine dehydrogenase) cyd,encoding a subunit of the cytochrome D ubiquinol oxidase, and gltA1, encoding a citrate synthase. Promoter activity in the upstream regions of both cydB and gltA1 was altered in the RegX3 deletion strain. DNA-binding assays confirmed that RegX3 binds to the promoter regions of ald, cydB and gltA1 in a phosphorylation-dependent manner. Taken together these data suggest a direct role for the SenX-RegX3 system in modulating expression of aerobic respiration, in addition to its role during phosphate limitation.
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