ArticlePloS one2011
Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Arc controls organ architecture through modulation of Crb and MyoII.The Journal of cell biology · 2025Article
- Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs.PLoS biology · 2025Article
- The AaFoxA factor regulates female reproduction through chromatin remodeling in the mosquito vector Aedes aegypti.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Venom gland organogenesis in the common house spider.Scientific reports · 2024Article
- Article
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.The Journal of cell biology · 2022Article
- Effective Oral RNA Interference (RNAi) Administration to Adult Anopheles gambiae Mosquitoes.Journal of visualized experiments : JoVE · 2022Article
- Transcriptional Control of Apical-Basal Polarity Regulators.International journal of molecular sciences · 2021Review
- Secrets of secretion-How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.Current topics in developmental biology · 2021Article
- Article
- LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication.Genes & development · 2018Article
- Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development.Developmental biology · 2016Article
- Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammation.World journal of methodology · 2015Review
- Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.Development (Cambridge, England) · 2013Article
- Hox targets and cellular functions.Scientifica · 2013Article
- Drosophila as a model for epithelial tube formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transcription factors drive organogenesis, from the initiation of cell fate decisions to the maintenance and implementation of these decisions. The Drosophila embryonic salivary gland provides an excellent platform for unraveling the underlying transcriptional networks of organ development because Drosophila is relatively unencumbered by significant genetic redundancy. The highly conserved FoxA family transcription factors are essential for various aspects of organogenesis in all animals that have been studied. Here, we explore the role of the single Drosophila FoxA protein Fork head (Fkh) in salivary gland organogenesis using two genome-wide strategies. A large-scale in situ hybridization analysis reveals a major role for Fkh in maintaining the salivary gland fate decision and controlling salivary gland physiological activity, in addition to its previously known roles in morphogenesis and survival. The majority of salivary gland genes (59%) are affected by fkh loss, mainly at later stages of salivary gland development. We show that global expression of Fkh cannot drive ectopic salivary gland formation. Thus, unlike the worm FoxA protein PHA-4, Fkh does not function to specify cell fate. In addition, Fkh only indirectly regulates many salivary gland genes, which is also distinct from the role of PHA-4 in organogenesis. Our microarray analyses reveal unexpected roles for Fkh in blocking terminal differentiation and in endoreduplication in the salivary gland and in other Fkh-expressing embryonic tissues. Overall, this study demonstrates an important role for Fkh in determining how an organ preserves its identity throughout development and provides an alternative paradigm for how FoxA proteins function in organogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.