ArticlePloS one2011
Fish oil enhances recovery of intestinal microbiota and epithelial integrity in chronic rejection of intestinal transplant.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Trending ileal microbiome dysbiosis over time as an early assessment of intestinal transplant rejection risk.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Intestinal reengineering: Scientific advances in intestinal transplantation.World journal of gastrointestinal surgery · 2025Review
- Dietary Lipids, Gut Microbiota, and Their Metabolites: Insights from Recent Studies.Nutrients · 2025Review
- Comprehensive Comparison of Effects of Antioxidant (Astaxanthin) Supplementation from Different Sources inAntioxidants (Basel, Switzerland) · 2023Article
- EndogenousNutrients · 2023Article
- Identification of food and nutrient components as predictors ofFrontiers in nutrition · 2023Article
- Innovations in Immunosuppression for Intestinal Transplantation.Frontiers in nutrition · 2022Review
- The Molecular and Mechanistic Insights Based on Gut-Liver Axis: Nutritional Target for Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement.International journal of molecular sciences · 2020Review
- Gut microbiota and its implications in small bowel transplantation.Frontiers of medicine · 2018Review
- Chronic Rejection After Intestinal Transplant: Where Are We in Order to Avert It?Digestive diseases and sciences · 2018Review
- Organ transplantation and gut microbiota: current reviews and future challenges.American journal of translational research · 2018Review
- Network analysis of gut microbiota literature: an overview of the research landscape in non-human animal studies.The ISME journal · 2017Review
- Gut microbiota and allogeneic transplantation.Journal of translational medicine · 2015Review
- A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia.Scientific reports · 2015Article
- Dynamics of gut microbiota in autoimmune lupus.Applied and environmental microbiology · 2014Article
- Intestinal microbial variation may predict early acute rejection after liver transplantation in rats.Transplantation · 2014Article
- Article
- Dynamic alteration of the colonic microbiota in intestinal ischemia-reperfusion injury.PloS one · 2012Article
- Molecular-phylogenetic characterization of the microbiota in ulcerated and non-ulcerated regions in the patients with Crohn's disease.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe intestinal chronic rejection (CR) is the major limitation to long-term survival of transplanted organs. This study aimed to investigate the interaction between intestinal microbiota and epithelial integrity in chronic rejection of intestinal transplantation, and to find out whether fish oil enhances recovery of intestinal microbiota and epithelial integrity. METHODS/PRINCIPAL
findingsThe luminal and mucosal microbiota composition of CR rats were characterized by DGGE analysis at 190 days after intestinal transplant. The specific bacterial species were determined by sequence analysis. Furthermore, changes in the localization of intestinal TJ proteins were examined by immunofluorescent staining. PCR-DGGE analysis revealed that gut microbiota in CR rats had a shift towards Escherichia coli, Bacteroides spp and Clostridium spp and a decrease in the abundance of Lactobacillales bacteria in the intestines. Fish oil supplementation could enhance the recovery of gut microbiota, showing a significant decrease of gut bacterial proportions of E. coli and Bacteroides spp and an increase of Lactobacillales spp. In addition, CR rats showed pronounced alteration of tight junction, depicted by marked changes in epithelial cell ultrastructure and redistribution of occuldin and claudins as well as disruption in TJ barrier function. Fish oil administration ameliorated disruption of epithelial integrity in CR, which was associated with an improvement of the mucosal structure leading to improved tight junctions. CONCLUSIONS/SIGNIFICANCE: Our study have presented novel evidence that fish oil is involved in the maintenance of epithelial TJ integrity and recovery of gut microbiota, which may have therapeutic potential against CR in intestinal transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.