ArticlePLoS genetics2011
Parallel adaptive divergence among geographically diverse human populations.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas.PLoS genetics · 2024Article
- Towards evolutionary predictions: Current promises and challenges.Evolutionary applications · 2023Review
- A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection.PLoS biology · 2022Article
- Genome Resequencing Reveals Rapid, Repeated Evolution in the Colorado Potato Beetle.Molecular biology and evolution · 2022Article
- Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes.Molecular biology and evolution · 2021Article
- Parallel genomic architecture underlies repeated sexual signal divergence in HawaiianProceedings. Biological sciences · 2019Article
- Genomics of disease risk in globally diverse populations.Nature reviews. Genetics · 2019Review
- Positive selection in Europeans and East-Asians at the ABCA12 gene.Scientific reports · 2019Article
- Global genetic differentiation of complex traits shaped by natural selection in humans.Nature communications · 2018Article
- FineMAV: prioritizing candidate genetic variants driving local adaptations in human populations.Genome biology · 2018Article
- Adaptation of human skin color in various populations.Hereditas · 2018Review
- Parallel Evolution of Cold Tolerance within Drosophila melanogaster.Molecular biology and evolution · 2017Article
- The genomics of ecological vicariance in threespine stickleback fish.Nature communications · 2015Article
- Genomic signatures reveal new evidences for selection of important traits in domestic cattle.Molecular biology and evolution · 2015Article
- Using genomics to characterize evolutionary potential for conservation of wild populations.Evolutionary applications · 2014Article
- Widespread signals of convergent adaptation to high altitude in Asia and america.American journal of human genetics · 2014Article
- The genomic signature of parallel adaptation from shared genetic variation.Molecular ecology · 2014Article
- Population-specific common SNPs reflect demographic histories and highlight regions of genomic plasticity with functional relevance.BMC genomics · 2014Article
- Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes.Brain and behavior · 2014Article
- Geographical, environmental and pathophysiological influences on the human blood transcriptome.Current genetic medicine reports · 2013Article
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2 authors.
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Abstract
Few genetic differences between human populations conform to the classic model of positive selection, in which a newly arisen mutation rapidly approaches fixation in one lineage, suggesting that adaptation more commonly occurs via moderate changes in standing variation at many loci. Detecting and characterizing this type of complex selection requires integrating individually ambiguous signatures across genomically and geographically extensive data. Here, we develop a novel approach to test the hypothesis that selection has favored modest divergence at particular loci multiple times in independent human populations. We find an excess of SNPs showing non-neutral parallel divergence, enriched for genic and nonsynonymous polymorphisms in genes encompassing diverse and often disease related functions. Repeated parallel evolution in the same direction suggests common selective pressures in disparate habitats. We test our method with extensive coalescent simulations and show that it is robust to a wide range of demographic events. Our results demonstrate phylogenetically orthogonal patterns of local adaptation caused by subtle shifts at many widespread polymorphisms that likely underlie substantial phenotypic diversity.
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