ArticlePLoS genetics2011
Trait variation in yeast is defined by population history.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 215 papers.
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Who cites it
215 citing papers in PubMed, 380 citations in OpenAlex.
- CYClones: a highly powered, fully genotyped, eight-parent yeast mapping population.G3 (Bethesda, Md.) · 2026Article
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- From Oak to Wine: Evolution, Admixture, and Adaptation of California and British Columbia Saccharomyces Cerevisiae Wine Strains.Genome biology and evolution · 2026Article
- Population-scale chemical response revealed by a barcoded yeast collection.Nature communications · 2026Article
- Divergent metallothionein strategies underlie copper tolerance in Saccharomyces species relevant to winemaking.Applied microbiology and biotechnology · 2026Article
- Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Template Switching as a Driver of Promoter Evolution in Yeast: Case Study of the GRE2 Gene.Genome biology and evolution · 2026Article
- Segmental copy number amplifications are more stable than aneuploidies in the absence of selection.Molecular biology and evolution · 2026Article
- The role of mitotype variation and positive epistasis in trait differences between Saccharomyces species.Genetics · 2026Article
- Discovery and validation of ASG1 as a novel determinant of NaCl tolerance in the yeast Saccharomyces cerevisiae through iterative crossing.G3 (Bethesda, Md.) · 2026Article
- Distribution of yeast species and their resistance to copper and sulfite across arboreal and viticulture habitats.FEMS yeast research · 2026Article
- Native oleaginous yeastsFrontiers in fungal biology · 2026Article
- Surprising regulatory plasticity for the conserved HOG pathway in diversebioRxiv : the preprint server for biology · 2025Article
- Technological and probiotic properties of lactic acid bacteria and yeasts isolated from Ghanaian spontaneously fermented pearl-millet porridge, Hausa koko.BMC microbiology · 2025Article
- Whole-Genome Sequencing and Phenotyping Reveal Specific Adaptations of Lachancea thermotolerans to the Winemaking Environment.Molecular ecology · 2025Article
- Article
- The effect of spontaneous mutations onbioRxiv : the preprint server for biology · 2025Article
- Predicting natural variation in the yeast phenotypic landscape with machine learning.Molecular systems biology · 2025Article
- Biocontainment efficacy redefined.Applied and environmental microbiology · 2025Article
- CYClones: A highly powered, fully genotyped, 8-parent yeast mapping population.bioRxiv : the preprint server for biology · 2025Article
155 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
A fundamental goal in biology is to achieve a mechanistic understanding of how and to what extent ecological variation imposes selection for distinct traits and favors the fixation of specific genetic variants. Key to such an understanding is the detailed mapping of the natural genomic and phenomic space and a bridging of the gap that separates these worlds. Here we chart a high-resolution map of natural trait variation in one of the most important genetic model organisms, the budding yeast Saccharomyces cerevisiae, and its closest wild relatives and trace the genetic basis and timing of major phenotype changing events in its recent history. We show that natural trait variation in S. cerevisiae exceeds that of its relatives, despite limited genetic variation, and follows the population history rather than the source environment. In particular, the West African population is phenotypically unique, with an extreme abundance of low-performance alleles, notably a premature translational termination signal in GAL3 that cause inability to utilize galactose. Our observations suggest that many S. cerevisiae traits may be the consequence of genetic drift rather than selection, in line with the assumption that natural yeast lineages are remnants of recent population bottlenecks. Disconcertingly, the universal type strain S288C was found to be highly atypical, highlighting the danger of extrapolating gene-trait connections obtained in mosaic, lab-domesticated lineages to the species as a whole. Overall, this study represents a step towards an in-depth understanding of the causal relationship between co-variation in ecology, selection pressure, natural traits, molecular mechanism, and alleles in a key model organism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.