ArticlePLoS computational biology2011
Impact of microscopic motility on the swimming behavior of parasites: straighter trypanosomes are more directional.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Fate of Trypanosoma cruzi, the causative agent of Chagas disease, in bed bugs after oral ingestion or intrathoracic injection.PLoS neglected tropical diseases · 2025Article
- Trajectory-driven computational analysis for element characterization in Trypanosoma cruzi video microscopy.PloS one · 2024Article
- Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional ciliary motility in Trypanosoma brucei.PLoS pathogens · 2022Article
- Transmigration ofiScience · 2022Article
- Motility patterns of Trypanosoma cruzi trypomastigotes correlate with the efficiency of parasite invasion in vitro.Scientific reports · 2020Article
- Motility Analysis of Trypanosomatids.Methods in molecular biology (Clifton, N.J.) · 2020Article
- High-speed multifocal plane fluorescence microscopy for three-dimensional visualisation of beating flagella.Journal of cell science · 2019Article
- Establishment of Larval Zebrafish as an Animal Model to Investigate Trypanosoma cruzi Motility In Vivo.Journal of visualized experiments : JoVE · 2017Article
- Use of chiral cell shape to ensure highly directional swimming in trypanosomes.PLoS computational biology · 2017Article
- Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies.PLoS pathogens · 2016Article
- A self-filling microfluidic device for noninvasive and time-resolved single red blood cell experiments.Biomicrofluidics · 2016Article
- Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.PLoS pathogens · 2016Article
- Transient Superdiffusion and Long-Range Correlations in the Motility Patterns of Trypanosomatid Flagellate Protozoa.PloS one · 2016Article
- Simulating the complex cell design of Trypanosoma brucei and its motility.PLoS computational biology · 2015Article
- Experimental and Mathematical-Modeling Characterization of Trypanosoma cruzi Epimastigote Motility.PloS one · 2015Article
- Knockdown of Inner Arm Protein IC138 in Trypanosoma brucei Causes Defective Motility and Flagellar Detachment.PloS one · 2015Article
- Optical trapping reveals propulsion forces, power generation and motility efficiency of the unicellular parasites Trypanosoma brucei brucei.Scientific reports · 2014Article
- Modelling and analysis of bacterial tracks suggest an active reorientation mechanism in Rhodobacter sphaeroides.Journal of the Royal Society, Interface · 2014Article
- Mouse infection and pathogenesis by Trypanosoma brucei motility mutants.Cellular microbiology · 2014Article
- Labour-efficient in vitro lymphocyte population tracking and fate prediction using automation and manual review.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms, particularly parasites, have developed sophisticated swimming mechanisms to cope with a varied range of environments. African Trypanosomes, causative agents of fatal illness in humans and animals, use an insect vector (the Tsetse fly) to infect mammals, involving many developmental changes in which cell motility is of prime importance. Our studies reveal that differences in cell body shape are correlated with a diverse range of cell behaviors contributing to the directional motion of the cell. Straighter cells swim more directionally while cells that exhibit little net displacement appear to be more bent. Initiation of cell division, beginning with the emergence of a second flagellum at the base, correlates to directional persistence. Cell trajectory and rapid body fluctuation correlation analysis uncovers two characteristic relaxation times: a short relaxation time due to strong body distortions in the range of 20 to 80 ms and a longer time associated with the persistence in average swimming direction in the order of 15 seconds. Different motility modes, possibly resulting from varying body stiffness, could be of consequence for host invasion during distinct infective stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.