ArticleBiomedical optics express2011
In vivo and ex vivo epi-mode pump-probe imaging of melanin and microvasculature.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- On the importance of simultaneous label-free multimodal nonlinear optical imaging for biomedical applications.APL photonics · 2025Article
- Recent Advances in Characterization of Melanin Pigments in Biological Samples.International journal of molecular sciences · 2023Review
- Optical characteristics of the skin with dark circles using pump-probe imaging.Scientific reports · 2022Article
- In vivo imaging with a fast large-area multiphoton exoscope (FLAME) captures the melanin distribution heterogeneity in human skin.Scientific reports · 2022Article
- In vivo melanin 3D quantification and z-epidermal distribution by multiphoton FLIM, phasor and Pseudo-FLIM analyses.Scientific reports · 2022Article
- Label-Free Delineation of Human Uveal Melanoma Infiltration With Pump-Probe Microscopy.Frontiers in oncology · 2022Article
- Melanin distribution from the dermal-epidermal junction to the stratum corneum: non-invasive in vivo assessment by fluorescence and Raman microspectroscopy.Scientific reports · 2020Article
- Transient absorption microscopy: Technological innovations and applications in materials science and life science.The Journal of chemical physics · 2020Article
- Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques.Scientific reports · 2019Article
- Analysis of skin morphological features and real-time monitoring using snapshot hyperspectral imaging.Biomedical optics express · 2019Article
- Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy.Translational vision science & technology · 2019Article
- Unraveling the molecular nature of melanin changes in metastatic cancer.Journal of biomedical optics · 2019Article
- Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions.Biomedical optics express · 2017Article
- Transient absorption imaging of hemes with 2-color, independently tunable visible-wavelength ultrafast source.Biomedical optics express · 2017Article
- Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.Journal of lower genital tract disease · 2017Article
- Dual-wavelength pump-probe microscopy analysis of melanin composition.Scientific reports · 2016Article
- Label-free photoacoustic tomography of whole mouse brain structuresNeurophotonics · 2016Article
- Invited Review Article: Pump-probe microscopy.The Review of scientific instruments · 2016Review
- Ultrafast transient absorption of eumelanin suspensions: the role of inverse Raman scattering.Biomedical optics express · 2015Article
- Pump-probe imaging of pigmented cutaneous melanoma primary lesions gives insight into metastatic potential.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We performed epi-mode pump-probe imaging of melanin in excised human pigmented lesions and both hemoglobin and melanin in live xenograft mouse melanoma models to depths greater than 100 µm. Eumelanin and pheomelanin images, which have been previously demonstrated to differentiate melanoma from benign lesions, were acquired at the dermal-epidermal junction with cellular resolution and modest optical powers (down to 15 mW). We imaged dermal microvasculature with the same wavelengths, allowing simultaneous acquisition of melanin, hemoglobin and multiphoton autofluorescence images. Molecular pump-probe imaging of melanocytes, skin structure and microvessels allows comprehensive, non-invasive characterization of pigmented lesions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.