ArticleBiomedical optics express2011
Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Uptake of fluorescent D- and L-glucose analogues, 2-NBDG and 2-NBDLG, into human osteosarcoma U2OS cells in a phloretin-inhibitable manner.Human cell · 2021Article
- Spatially resolved measurement of dynamic glucose uptake in live ex vivo tissues.Analytica chimica acta · 2021Article
- L-Glucose: Another Path to Cancer Cells.Cancers · 2020Review
- Biomarker selection and imaging design in cancer: A link with biochemical pathways for imminent engineering.Heliyon · 2020Review
- Detection of Head and Neck Cancer in Surgical Specimens Using Quantitative Hyperspectral Imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Imaging hamster model of bile duct cancer in vivo using fluorescent L-glucose derivatives.Human cell · 2016Article
- Uptake of a fluorescent L-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner.Human cell · 2016Article
- Vital-dye-enhanced multimodal imaging of neoplastic progression in a mouse model of oral carcinogenesis.Journal of biomedical optics · 2013Article
- Mitigating fluorescence spectral overlap in wide-field endoscopic imaging.Journal of biomedical optics · 2013Article
- 2-NBDG fluorescence imaging of hypermetabolic circulating tumor cells in mouse xenograft model of breast cancer.Journal of fluorescence · 2013Article
- Article
- Advances in molecular imaging: targeted optical contrast agents for cancer diagnostics.Nanomedicine (London, England) · 2012Review
- Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells.Journal of oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specimens acquired before and after incubation with 2-NBDG demonstrated increased fluorescent signal in all of the malignant tissue due to increased 2-NBDG consumption. We demonstrate that 2-NBDG has potential as an optical contrast agent to differentiate cancerous from non-cancerous tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.