ArticleBiomedical optics express2011
Experimental investigation of NIRS spatial sensitivity.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Functional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review.American journal of speech-language pathology · 2020Pooled it
- Functional near-infrared spectroscopy (fNIRS) in medical research: applications, opportunities, and challenges.Chinese medicine · 2026Review
- Cognitive state monitoring for neuroadaptive information visualization.Frontiers in human neuroscience · 2026Review
- Design and development of a portable multiwavelength LED-based diffuse reflectance spectroscopy tool for rapid breast cancer identification.Scientific reports · 2025Article
- Exploring Imagined Movement for Brain-Computer Interface Control: An fNIRS and EEG Review.Brain sciences · 2025Review
- Opportunities and challenges for deep brain stimulation electrode-guided neurofeedback for symptom mitigation in neurological and psychiatric disorders.Journal of neuroengineering and rehabilitation · 2025Review
- Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review.Developmental medicine and child neurology · 2025Article
- Intelligent Neonatal Blood Perfusion Assessment System Based on Near-Infrared Spectroscopy.IEEE journal of translational engineering in health and medicine · 2025Article
- Ipsilateral stimulation shows somatotopy of thumb and shoulder auricular points on the left primary somatosensory cortex using high-density fNIRS.bioRxiv : the preprint server for biology · 2024Article
- Ultrasound Diagnosis and Near-Infrared Spectroscopy in the Study of Encephalopathy in Neonates Born under Asphyxia: Narrative Review.Children (Basel, Switzerland) · 2024Review
- Monte Carlo simulation of the effect of melanin concentration on light-tissue interactions in transmittance and reflectance finger photoplethysmography.Scientific reports · 2024Article
- Near-infrared spectroscopy for kidney oxygen monitoring in a porcine model of hemorrhagic shock, hemodilution, and REBOA.Scientific reports · 2024Article
- Feasibility study of functional near-infrared spectroscopy in the ventral visual pathway for real-life applications.Neurophotonics · 2024Article
- Differential effects of hypnotherapy and cognitive behavioral therapy on the default mode network of depressed patients.Frontiers in psychology · 2024Article
- On the coupling and decoupling of mind wandering and perception: a shared metabolism account.Cerebral cortex communications · 2023Article
- Altered microvascular reactivity assessed by near-infrared spectroscopy after hepato-pancreato-biliary surgery.Journal of clinical monitoring and computing · 2022Observational
- Hemodynamic Function of Forearm Muscle in Postmenopausal Women With Type 2 Diabetes.Journal of aging and physical activity · 2020Article
- The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience.Annals of the New York Academy of Sciences · 2020Review
- Applications of Functional Near-Infrared Spectroscopy (fNIRS) Neuroimaging in Exercise⁻Cognition Science: A Systematic, Methodology-Focused Review.Journal of clinical medicine · 2018Review
- A Review on the Use of Wearable Functional Near-Infrared Spectroscopy in Naturalistic EnvironmentsThe Japanese psychological research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Near infrared spectroscopy (NIRS) is regarded as a potential medical diagnostic technique for investigation of hemodynamic changes. However, uncertainties pertaining to the origin of NIRS signals have hampered its clinical interpretation. The uncertainities in NIRS measurements especially in case of living tissues are due to lack of rigorous combined theoretical-experimental studies resulting in clear understanding of the origin of NIRS signals. For their reliable interpretation it is important to understand the relationship between spatial changes in optical properties and corresponding changes in the NIRS signal. We investigated spatial sensitivity of near infrared optical measurements using an experimental approach. It uses a liquid optical phantom as tissue equivalent, which is explored under robot-control by a small, approximately point like perturbation of desired optical properties, and a NIRS instrument for trans-illumination/reflection measurements. The experimentally obtained sensitivity has been analyzed and compared with numerical simulations. In preliminary experiments we investigated the influence of various optical properties of the medium and of source/detector distances on the spatial sensitivity distribution. The acquired sensitivity maps can be used to define characteristic parameters. As an example, we used a 25% threshold to define a penetration depth measure which provides values in good accordance with published ones. To the best of our knowledge this is the first experimental study of NIRS spatial sensitivity. The presented method will allow in depth experimental investigation of the influence of various conditions pertaining to medium such as optical properties of tissue (scattering and absorption) and of the source/detector configuration.
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