ArticleEvolutionary bioinformatics online2011
Evolutionary Implications and Physicochemical Analyses of Selected Proteins of Type III Polyketide Synthase Family.
Article in Evolutionary bioinformatics online, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
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- Comprehensive Analysis ofInternational journal of molecular sciences · 2023Article
- A wound inducible chalcone synthase gene fromPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Bioinformatics approaches for classification and investigation of the evolution of the Na/K-ATPase alpha-subunit.BMC ecology and evolution · 2022Article
- Genome Mining and Evolutionary Analysis Reveal Diverse Type III Polyketide Synthase Pathways in Cyanobacteria.Genome biology and evolution · 2021Article
- Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria.Journal of industrial microbiology & biotechnology · 2019Article
- Type III polyketide synthase repertoire in Zingiberaceae: computational insights into the sequence, structure and evolution.Development genes and evolution · 2016Article
- Tandem expression in E. coli of type III PKS and P450 genes from marine Streptomyces olivaceus FXJ 7.023 gives production of phenol and indole.World journal of microbiology & biotechnology · 2015Article
- Genome wide in silico characterization of Dof gene families of pigeonpea (Cajanus cajan (L) Millsp.).Molecular biology reports · 2015Article
- Article
- The pectin lyases in Arabidopsis thaliana: evolution, selection and expression profiles.PloS one · 2012Article
- Enzymatic properties and mutational studies of chalcone synthase from Physcomitrella patens.International journal of molecular sciences · 2012Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Type III polyketide synthases have a substantial role in the biosynthesis of various polyketides in plants and microorganisms. Comparative proteomic analysis of type III polyketide synthases showed evolutionarily and structurally related positions in a compilation of amino acid sequences from different families. Bacterial and fungal type III polyketide synthase proteins showed <50% similarity but in higher plants, it exhibited >80% among chalcone synthases and >70% in the case of non-chalcone synthases. In a consensus phylogenetic tree based on 1000 replicates; bacterial, fungal and plant proteins were clustered in separate groups. Proteins from bryophytes and pteridophytes grouped immediately near to the fungal cluster, demonstrated how evolutionary lineage has occurred among type III polyketide synthase proteins. Upon physicochemical analysis, it was observed that the proteins localized in the cytoplasm and were hydrophobic in nature. Molecular structural analysis revealed comparatively stable structure comprising of alpha helices and random coils as major structural components. It was found that there was a decline in the structural stability with active site mutation as prophesied by the in silico mutation studies.
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