ArticleSurgical neurology international2011
Histiocytosis X: Characteristics, behavior, and treatments as illustrated in a case series.
Article in Surgical neurology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Ophthalmic histiocytic lesions: a baseline demographic and clinicopathological study of 28 cases from two eye centers.International ophthalmology · 2022Article
- Three decades of progress from surgery to medical therapy for isolated neuroaxisJournal of neurosurgery. Case lessons · 2021Article
- Spontaneous Thyroid Hemorrhage Caused by Langerhans Cell Histiocytosis: A Case Report and Literature Review.Frontiers in endocrinology · 2021Review
- Langerhans' cell histiocytosis of the temporal bone: A case report.Experimental and therapeutic medicine · 2017Article
- Bone Langerhans cell histiocytosis with pulmonary involvement in an adult non-smoker: A case report and brief review of the literature.Molecular and clinical oncology · 2017Article
- A 22-Year Old Woman with Right Eyelid Swelling.Brain pathology (Zurich, Switzerland) · 2016Article
- Case of Langerhans Cell Histiocytosis That Mimics Meningioma in CT and MRI.Journal of Korean Neurosurgical Society · 2016Article
- Langerhans cell histiocytosis with multisystem involvement in an infant: A case report.Experimental and therapeutic medicine · 2015Article
- Eosinophilic granuloma/Langerhans cell histiocytosis: Pediatric neurosurgery update.Surgical neurology international · 2015Article
- Langerhans cell histiocytosis mimicking osteomyelitis in an infant.APSP journal of case reports · 2013Article
- Unifocal langerhans cell histiocytosis simulating a limbal papilloma.Journal of ophthalmic & vision research · 2012Article
- Langerhans cell histiocytosis of the cranial base: is low-dose radiotherapy effective?Case reports in oncological medicine · 2012Article
- Langerhans' cell histiocytosis involving posterior elements of the dorsal spine: An unusual cause of extradural spinal mass in an adult.Journal of craniovertebral junction & spine · 2011Article
- Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature.Survey of ophthalmologyReview
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLangerhans cell histiocytosis (LCH) is a proliferative disorder predominantly found in children. It often presents with pain in calvarium or spine and may cause neuroendocrine symptoms. The gold standard for diagnosing LCH is the detection of Birbeck Granules by EM. Here, we describe two unique presentations of LCH and we review current treatment guidelines. CASE DESCRIPTION: The first patient was a 23-year-old man who presented with progressive swelling and redness of the left eye. MRI revealed a left retrobulbar lesion extending into the middle cranial fossa with no signal abnormality in the brain parenchyma. The lesion was resected and pathological analysis revealed LCH. Bone scans were negative and the patient was discharged soon after. He later underwent fractionated radiotherapy (cumulative dose 26 Gy). Follow-up MRIs show no disease at 24 months post-op. The second patient was a 56-year-old man with left frontal skull pain for 5 months. Imaging showed a solitary osteolytic lesion extending into both dura and scalp with no signal abnormality of the parenchyma. Excisional biopsy revealed LCH. Surgery was well tolerated and follow-up imaging shows no recurrence at 24 months post-op.
conclusionWe demonstrate that LCH, though uncommon, must remain on the differential when osteolytic lesions present in the adult. Although LCH often has the clinical and radiographical presentation of an abscess, pathology analysis can successfully diagnose LCH based on markers and morphological characteristics. LCH has an excellent prognosis when treated aggressively with surgical resection and radiotherapy as both of our patients were and are now disease free at 2 year follow-up.
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