ArticleThe ISME journal2012
The significance of nitrogen cost minimization in proteomes of marine microorganisms.
Article in The ISME journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
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- Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation.Nature microbiology · 2026Article
- Microbial population structure along the water columns and sediments in the Diamantina and Kermadec trenches.BMC biology · 2025Article
- The chitin raft hypothesis for the colonization of the open ocean by cyanobacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
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- Synthesis of a Truncated Microcystin Tetrapeptide Molecule from a Partial Mcy Gene Cluster in Microcystis Cultures and Blooms.Environmental science & technology · 2024Article
- Unveiling the unknown viral world in groundwater.Nature communications · 2024Article
- Genome streamlining in Parcubacteria transitioning from soil to groundwater.Environmental microbiome · 2024Article
- Genome-scale community modelling reveals conserved metabolic cross-feedings in epipelagic bacterioplankton communities.Nature communications · 2024Article
- Metagenome-assembled genomes reveal greatly expanded taxonomic and functional diversification of the abundant marine Roseobacter RCA cluster.Microbiome · 2023Article
- Genomic analysis of the marine yeast Rhodotorula sphaerocarpa ETNP2018 reveals adaptation to the open ocean.BMC genomics · 2023Article
- Delving into the lifestyle of Sundarban Wetland resident, biofilm producing, halotolerant Salinicoccus roseus: a comparative genomics-based intervention.BMC genomics · 2023Article
- Taxonomic and carbon metabolic diversification of Bathyarchaeia during its coevolution history with early Earth surface environment.Science advances · 2023Article
- Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Abiotic selection of microbial genome size in the global ocean.Nature communications · 2023Article
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- Stochastic and Deterministic Processes Regulate Phytoplankton Assemblages in a Temperate Coastal Ecosystem.Microbiology spectrum · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine microorganisms thrive under low levels of nitrogen (N). N cost minimization is a major selective pressure imprinted on open-ocean microorganism genomes. Here we show that amino-acid sequences from the open ocean are reduced in N, but increased in average mass compared with coastal-ocean microorganisms. Nutrient limitation exerts significant pressure on organisms supporting the trade-off between N cost minimization and increased average mass of amino acids that is a function of increased A+T codon usage. N cost minimization, especially of highly expressed proteins, reduces the total cellular N budget by 2.7-10%; this minimization in combination with reduction in genome size and cell size is an evolutionary adaptation to nutrient limitation. The biogeochemical and evolutionary precedent for these findings suggests that N limitation is a stronger selective force in the ocean than biosynthetic costs and is an important evolutionary strategy in resource-limited ecosystems.
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