ArticleMolecules (Basel, Switzerland)2011
Synthesis and characterization of (Z)-5-arylmethylidene-rhodanines with photosynthesis-inhibiting properties.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Synthesis and Evaluation of 5-Heteroarylidene-2-thioxo-4-thiazolidinones as PIM1 Kinase Inhibitors.Molecules (Basel, Switzerland) · 2026Article
- Thiazolidinones: novel insights from microwave synthesis, computational studies, and potentially bioactive hybrids.Beilstein journal of organic chemistry · 2025Article
- Article
- Synthesis of 5-arylidenerhodanines in L-proline-based deep eutectic solvent.Beilstein journal of organic chemistry · 2023Article
- Polyhalonitrobutadienes as Versatile Building Blocks for the Biotargeted Synthesis of Substituted N-Heterocyclic Compounds.Molecules (Basel, Switzerland) · 2020Article
- Investigation of Hydro-Lipophilic Properties ofMolecules (Basel, Switzerland) · 2018Article
- New 5-ylidene rhodanine derivatives based on the dispacamide A model.Molecular diversity · 2014Article
- Chemistry of polyhalogenated nitrobutadienes, 14: Efficient synthesis of functionalized (Z)-2-allylidenethiazolidin-4-ones.Beilstein journal of organic chemistry · 2014Article
- A simple and green procedure for the synthesis of 5-arylidenerhodanines catalyzed by diammonium hydrogen phosphate in water.TheScientificWorldJournal · 2013Article
- Three-component, one-flask synthesis of rhodanines (thiazolidinones).The Journal of organic chemistry · 2011Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts and reduce chlorophyll content in freshwater alga Chlorella vulgaris. Structure-activity relationships between the chemical structure, physical properties and biological activities of the evaluated compounds are discussed. For majority of the tested compounds the lipophilicity of the compound and not electronic properties of the R1 substituent were decisive for PET-inhibiting activity. The most potent PET inhibitor was (5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC(50) = 3.0 μmol/L) and the highest antialgal activity was exhibited by (5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC(50) = 1.3 μmol/L).
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