Evidence map›Paper›PMID 21697727›Full record

ArticleJournal of cardiovascular pharmacology2011

The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2.Lewis rat.

Exazevia M Logan, Azeez A Aileru, Hossam A Shaltout, David B Averill, Debra I Diz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Brain renin-angiotensin system in the nexus of hypertension and aging.Hypertension research : official journal of the Japanese Society of Hypertension · 2013
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Exazevia M LoganDepartment of Life Sciences and Biomedical Research Infrastructure Center, Winston-Salem State University, Winston-Salem, NC, USA.
Azeez A Aileru
Hossam A Shaltout
David B Averill
Debra I Diz
Wake Forest University · US

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 1994 to 2019
$34.8M
Wake Forest University School of Medicine PREP ScholarsR25GM064249 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DIZ, DEBRA I · 2001 to 2017
$4.8M
RESEARCH COREP20MD002303 · NIMHD · WINSTON-SALEM STATE UNIVERSITY · PI FLACK, SYLVIA A · 2007 to 2011
$4.7M
Mechanisms of Activity-Dependent Synaptic PlasticityK01HL067700 · NHLBI · WINSTON-SALEM STATE UNIVERSITY · PI AILERU, AZEEZ A · 2001 to 2005
$572k
The Role of Signal Transduction Pathways in HypertensionF31HL085927 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOGAN, EXAZEVIA M · 2006 to 2007
$72k
NHLBI NIH HHS F31 HL085927NHLBI NIH HHS K01 HL067700NHLBI NIH HHS P01 HL051952NHLBI NIH HHS P01 HL-51952NHLBI NIH HHS P20 HL-67700NIGMS NIH HHS GM64249NIGMS NIH HHS R25 GM064249NIMHD NIH HHS MD002303NIMHD NIH HHS P20 MD002303
6 · The paper itself

Abstract

The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway in brain of spontaneously hypertensive rats, but not Wistar-Kyoto (WKY) rats, contributes to elevated mean arterial pressure (MAP). The role of PI3K in the regulation of blood pressure or autonomic function in the nucleus tractus solitarii (NTS) is yet to be established in other Ang II-dependent models of hypertension. Thus, we microinjected PI3K inhibitors, wortmannin or LY294002, into the NTS, and measured MAP, baroreflex sensitivity (BRS) for heart rate (HR) control, and HR variability (HRV) in mRen2.Lewis congenic and (mRen2)27 transgenic rats. Bilateral NTS microinjections of wortmannin (100 nmol/L; 50 nL) reduced MAP in (mRen2)27 and mRen2.Lewis rats (33 ± 5 mm Hg, n = 7, and 32 ± 6 mm Hg, n = 9, respectively) for approximately 90 minutes. Spectral and sequence analysis showed improvements in spontaneous BRS and HRV (50%-100%) after treatment in both hypertensive strains. Injections of wortmannin into NTS of Hannover Sprague-Dawley or Lewis control rats failed to alter MAP, BRS, or HRV. In mRen2.Lewis, but not in control Lewis rats, LY294002 (50 μmole/L) reduced MAP and increased BRS and HRV similar to wortmannin. Thus, the pharmacologic blockade of the PI3K signaling pathway in NTS reveals an important contribution to resting MAP and BRS in rats with overexpression of the Ren2 gene.

Indexed as

AndrostadienesAnimalsBaroreflexBlood PressureChromonesHeart RateMaleMorpholinesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsRatsRats, Inbred LewRats, TransgenicReninSignal TransductionWortmannin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneAndrostadienesChromonesMorpholinesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsRen2 protein, mouseReninWortmannin

Identifiers

PMID21697727
PMCPMC3188661
OpenAlexW2004645446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.