ArticleRestorative neurology and neuroscience2011
Horizontal ladder task-specific re-training in adult rats with contusive thoracic spinal cord injury.
Article in Restorative neurology and neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Safe subdural administration and retention of a neurotrophin-3-delivering hydrogel in a rat model of spinal cord injury.Scientific reports · 2024Article
- Addition of angled rungs to the horizontal ladder walking task for more sensitive probing of sensorimotor changes.PloS one · 2021Article
- Effective robotic assistive pattern of treadmill training for spinal cord injury in a rat model.Experimental and therapeutic medicine · 2018Article
- Erythropoietin facilitates the recruitment of bone marrow mesenchymal stem cells to sites of spinal cord injury.Experimental and therapeutic medicine · 2017Article
- PROJECT HEAVEN: Preoperative Training in Virtual Reality.Surgical neurology international · 2017Article
- Accelerating locomotor recovery after incomplete spinal injury.Annals of the New York Academy of Sciences · 2013Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeUsing the horizontal ladder task, we examined some issues that need to be resolved before task-specific rehabilitative training can be employed clinically for the frequent contusive spinal cord injury (SCI). We hypothesized that improving recovery in task performance after contusive thoracic SCI requires frequent re-training and initiating the re-training early during spontaneous recovery.
methodsContusive SCI was produced at the adult female Sprague Dawley rat T10 vertebra. Task re-training was initiated one week later when occasional weight-supported plantar steps were taken overground (n = 8). It consisted of 2 repetitions each day, 5 days each week, for 3 weeks. Task performance and overground locomotion were assessed weekly. Neurotransmission through the SCI ventrolateral funiculus was examined. SCI morphometry was determined.
resultsRe-training did not improve task performance recovery compared to untrained Controls (n = 7). Untrained overground locomotion and neurotransmission through the SCI did not change. Lesion area at the injury epicenter as a percentage of the total spinal cord area as well as total tissue, lesion, and spared tissue, white matter, or gray matter volumes did not differ.
conclusionsFor the horizontal ladder task after contusive thoracic SCI, earlier re-training sessions with more repetitions and critical neural circuitry may be necessary to engender a rehabilitation effect.
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