ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Effect of pulmonary TNF-α overexpression on mouse isolated skeletal muscle function.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Cigarette smoke exposure impairs early-stage recovery from lengthening contraction-induced muscle injury in male mice.Physiological reports · 2024Article
- E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice.The Journal of physiology · 2018Article
- Hypoxic Preconditioning Attenuates Reoxygenation-Induced Skeletal Muscle Dysfunction in Aged Pulmonary TNF-α Overexpressing Mice.Frontiers in physiology · 2018Article
- Article
- Effects of Ionizing Irradiation on Mouse Diaphragmatic Skeletal Muscle.Frontiers in physiology · 2017Article
- Article
- Copper Deficiency in the Lungs of TNF-α Transgenic Mice.Frontiers in physiology · 2016Article
- Can resistive breathing injure the lung? Implications for COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2016Article
- Molecular Regulation of Toll-like Receptors in Asthma and COPD.Frontiers in physiology · 2015Review
- Article
- Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- TNF signals via neuronal-type nitric oxide synthase and reactive oxygen species to depress specific force of skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
TNF-α is a proinflammatory cytokine that is involved in numerous pathological processes including chronic obstructive pulmonary disease (COPD). In the present study, we used a transgenic mouse model that overexpresses TNF-α in the lung (Tg(+)) to test the hypothesis that chronic exposure to TNF-α (as seen in COPD) reduces skeletal muscle force production and fatigue resistance, particularly under low Po(2) conditions. At 7-12 mo, body and muscle weight of both extensor digitorum longus (EDL) and soleus were significantly smaller in Tg(+) compared with littermate wild-type (WT) mice; however, the body-to-muscle weight ratio was not different between groups. EDL and soleus muscles were subjected to in vitro fatiguing contractile periods under high (∼550 Torr) and low Po(2) (∼40 Torr). Although all muscles were less fatigue-resistant during low Po(2) compared with high Po(2), only the soleus fatigued more rapidly in Tg(+) mice (∼12%) compared with WT at high Po(2). The maximal tension of EDL was equally reduced in Tg(+) mice (28-34% decrease from WT under both Po(2) conditions); but for soleus this parameter was smaller only under low Po(2) in Tg(+) mice (∼31% decrease from WT). The peak rate of relaxation and the peak rate of contraction were both significantly reduced in Tg(+) EDL muscles compared with WT EDL under low Po(2) conditions, but not in soleus. These results demonstrate that TNF-α upregulation in the lung impairs peripheral skeletal muscle function but affects fast- and slow-twitch muscles differentially at high and low Po(2).
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Registered trials
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