ArticleJournal of neurophysiology2011
Effects of persistent inward currents, accommodation, and adaptation on motor unit behavior: a simulation study.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- 5-HTThe Journal of physiology · 2025Trial
- Use of cyproheptadine hydrochloride (HCl) to reduce neuromuscular hypertonicity in stroke survivors: A Randomized Trial: Reducing Hypertonicity in Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Trial
- Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans.The Journal of physiology · 2026Article
- Analysis of motor units with high-density surface electromyography: methodological considerations and physiological significance.European journal of applied physiology · 2026Review
- Higher dominant muscle strength is mediated by motor unit discharge rates and proportion of common synaptic inputs.Scientific reports · 2025Article
- Effects of reciprocal inhibition and whole-body relaxation on persistent inward currents estimated by two different methods.The Journal of physiology · 2022Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults.GeroScience · 2021Article
- Firing rate trajectories of human occipitofrontalis motor units in response to triangular voluntary contraction intensity.Experimental brain research · 2021Article
- Estimates of persistent inward currents are reduced in upper limb motor units of older adults.The Journal of physiology · 2021Article
- Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans.Journal of neurophysiology · 2021Article
- Differences in estimated persistent inward currents between ankle flexors and extensors in humans.Journal of neurophysiology · 2020Article
- Estimation of self-sustained activity produced by persistent inward currents using firing rate profiles of multiple motor units in humans.Journal of neurophysiology · 2020Article
- Nonlinear Input-Output Functions of Motoneurons.Physiology (Bethesda, Md.) · 2020Review
- Estimates of persistent inward current in human motor neurons during postural sway.Journal of neurophysiology · 2019Article
- A motor unit-based model of muscle fatigue.PLoS computational biology · 2017Article
- Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study.Journal of neurophysiology · 2015Article
- Intrinsic excitability of human motoneurons in biceps brachii versus triceps brachii.Journal of neurophysiology · 2015Article
- Motor unit firing rates during spasms in thenar muscles of spinal cord injured subjects.Frontiers in human neuroscience · 2014Article
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2 authors.
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Abstract
Motor neurons are often assumed to generate spikes in proportion to the excitatory synaptic input received. There are, however, many intrinsic properties of motor neurons that might affect this relationship, such as persistent inward currents (PICs), spike-threshold accommodation, or spike-frequency adaptation. These nonlinear properties have been investigated in reduced animal preparation but have not been well studied during natural motor behaviors because of the difficulty in characterizing synaptic input in intact animals. Therefore, we studied the influence of each of these intrinsic properties on spiking responses and muscle force using a population model of motor units that simulates voluntary contractions in human subjects. In particular, we focused on the difference in firing rate of low-threshold motor units when higher threshold motor units were recruited and subsequently derecruited, referred to as ΔF. Others have used ΔF to evaluate the extent of PIC activation during voluntary behavior. Our results showed that positive ΔF values could arise when any one of these nonlinear properties was included in the simulations. Therefore, a positive ΔF should not be considered as exclusive evidence for PIC activation. Furthermore, by systematically varying contraction duration and speed in our simulations, we identified a means that might be used experimentally to distinguish among PICs, accommodation, and adaptation as contributors to ΔF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.