ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Epigenetic modulation rescues neurodevelopmental deficits in Syngap1Aging cell · 2025Article
- Electroporation Techniques to Target Subependymal Zone Neurogenic Niche.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation.PLoS biology · 2024Article
- The role of primary cilia in congenital heart defect-associated neurological impairments.Frontiers in genetics · 2024Review
- Bulk and mosaic deletions ofiScience · 2023Article
- Transcriptional control of embryonic and adult neural progenitor activity.Frontiers in neuroscience · 2023Review
- Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain.GeroScience · 2022Article
- Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus.Fluids and barriers of the CNS · 2022Article
- Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.Nature communications · 2022Article
- Impact of Motile Ciliopathies on Human Development and Clinical Consequences in the Newborn.Cells · 2021Review
- Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4.The EMBO journal · 2021Article
- Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.Cell reports · 2021Article
- Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium.Life science alliance · 2020Article
- Building bridges, not walls: spinal cord regeneration in zebrafish.Disease models & mechanisms · 2020Review
- Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals.Frontiers in neuroscience · 2020Review
- A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP.Chemical senses · 2019Article
- Article
- Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability.EBioMedicine · 2018Article
- Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus.Nature communications · 2018Article
- Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Establishment of a neural stem cell niche in the postnatal subependymal zone (SEZ) and the rostral migratory stream (RMS) is required for postnatal and adult neurogenesis in the olfactory bulbs (OB). We report the discovery of a cellular lineage in the SEZ-RMS-OB continuum, the specification of which is dependent on the expression of the forkhead transcription factor Foxj1 in mice. Spatially and temporally restricted Foxj1+ neuronal progenitors emerge during embryonic periods, surge during perinatal development, and are active only for the first few postnatal weeks. We show that the development of the unique Foxj1-derived lineage is dependent on Foxj1 expression and is required for overall postnatal neurogenesis in the OB. Strikingly, the production of neurons from Foxj1+ progenitors significantly declines after the early postnatal weeks, but Foxj1-derived neurons in the OB persist during adult periods. For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.