ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
First spike latency code for interaural phase difference discrimination in the guinea pig inferior colliculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Spatial separation between two sounds affects first-spike latencies of responses elicited by the sounds in the rat's auditory midbrain neurons.Scientific reports · 2025Article
- DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy.Frontiers in pharmacology · 2025Article
- Neural Adaptation at Stimulus Onset and Speed of Neural Processing as Critical Contributors to Speech Comprehension Independent of Hearing Threshold or Age.Journal of clinical medicine · 2024Article
- Article
- Intensity discrimination and neural representation of a masked tone in the presence of three types of masking release.Frontiers in neuroscience · 2023Article
- Neural readout of a latency code in the active electrosensory system.Cell reports · 2022Article
- Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of NaMolecular neurobiology · 2020Article
- Spatial hearing ability of the pigmented Guinea pig (Cavia porcellus): Minimum audible angle and spatial release from masking in azimuth.Hearing research · 2018Article
- Article
- Development of the head, pinnae, and acoustical cues to sound location in a precocial species, the guinea pig (Cavia porcellus).Hearing research · 2017Article
- Influence of envelope waveform on ITD sensitivity of neurons in the auditory midbrain.Journal of neurophysiology · 2017Article
- A Readout Mechanism for Latency Codes.Frontiers in computational neuroscience · 2016Article
- Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life.Cell and tissue research · 2015Review
- The acoustical cues to sound location in the guinea pig (Cavia porcellus).Hearing research · 2014Article
- Reading spike timing without a clock: intrinsic decoding of spike trains.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Temporal properties of responses to sound in the ventral nucleus of the lateral lemniscus.Journal of neurophysiology · 2014Article
- Comparison of latency and rate coding for the direction of whisker deflection in the subcortical somatosensory pathway.Journal of neurophysiology · 2012Article
- Ongoing temporal coding of a stochastic stimulus as a function of intensity: time-intensity trading.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurons with stereotyped and rapid responses provide a reference frame for relative temporal coding in primate auditory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Fast coding of orientation in primary visual cortex.PLoS computational biology · 2012Article
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Authors and funding
5 authors.
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Abstract
First spike latency has been suggested as a source of the information required for fast discrimination tasks. However, the accuracy of such a mechanism has not been analyzed rigorously. Here, we investigate the utility of first spike latency for encoding information about the location of a sound source, based on the responses of inferior colliculus (IC) neurons in the guinea pig to interaural phase differences (IPDs). First spike latencies of many cells in the guinea pig IC show unimodal tuning to stimulus IPD. We investigated the discrimination accuracy of a simple latency code that estimates stimulus IPD from the preferred IPD of the single cell that fired first. Surprisingly, despite being based on only a single spike, the accuracy of the latency code is comparable to that of a conventional rate code computed over the entire response. We show that spontaneous firing limits the capacity of the latency code to accumulate information from large neural populations. This detrimental effect can be overcome by generalizing the latency code to estimate the stimulus IPD from the preferred IPDs of the population of cells that fired the first n spikes. In addition, we show that a good estimate of the neural response time to the stimulus, which can be obtained from the responses of the cells whose response latency is invariant to stimulus identity, limits the detrimental effect of spontaneous firing. Thus, a latency code may provide great improvement in response speed at a small cost to the accuracy of the decision.
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