ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Central representation of postingestive chemosensory cues in mice that lack the ability to taste.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Genetic Deletion of TrpV1 and TrpA1 Does Not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice.Chemical senses · 2020Article
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Neuronal connections of the central amygdalar nucleus with refeeding-activated brain areas in rats.Brain structure & function · 2018Article
- 5-HTThe Journal of comparative neurology · 2017Article
- Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice.The Journal of comparative neurology · 2017Article
- Flavor Preferences Conditioned by Dietary Glutamate.Advances in nutrition (Bethesda, Md.) · 2016Review
- Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study.Neuroscience · 2016Article
- MSG-Evoked c-Fos Activity in the Nucleus of the Solitary Tract Is Dependent upon Fluid Delivery and Stimulation Parameters.Chemical senses · 2016Article
- Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice.Physiology & behavior · 2015Article
- The importance of the presence of a 5'-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of L-glutamate as assessed psychophysically.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice.Chemical senses · 2014Article
- Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice.Physiology & behavior · 2014Article
- Article
- Prior cold water swim stress alters immobility in the forced swim test and associated activation of serotonergic neurons in the rat dorsal raphe nucleus.Neuroscience · 2013Article
- Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.The European journal of neuroscience · 2013Article
- Reactive microglia after taste nerve injury: comparison to nerve injury models of chronic pain.F1000Research · 2013Article
- Glial responses after chorda tympani nerve injury.The Journal of comparative neurology · 2012Article
- Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice.Chemical senses · 2012Article
- Role of gut nutrient sensing in stimulating appetite and conditioning food preferences.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The gustatory nerves of mice lacking P2X2 and P2X3 purinergic receptor subunits (P2X-dblKO) are unresponsive to taste stimulation (Finger et al., 2005). Surprisingly, P2X-dblKO mice show residual behavioral responses to concentrated tastants, presumably via postingestive detection. Therefore, the current study tested whether postingestive signaling is functional in P2X-dblKO mice and if so, whether it activates the primary viscerosensory nucleus of the medulla, the nucleus of the solitary tract (nTS). Like WT animals, P2X-dblKO mice learned to prefer a flavor paired with 150 mm monosodium glutamate (MSG) over a flavor paired with water. This preference shows that, even in the absence of taste sensory input, postingestive cues are detected and associated with a flavor in P2X-dblKO mice. MSG-evoked neuronal activation in the nTS was measured by expression of the immediate early gene c-Fos [c-Fos-like immunoreactivity (Fos-LI)]. In rostral, gustatory nTS, P2X-dblKO animals, unlike WT animals, showed no taste quality-specific labeling of neurons. Furthermore, MSG-evoked Fos-LI was significantly less in P2X-dblKO mice compared with WT animals. In contrast, in more posterior, viscerosensory nTS, MSG-induced Fos-LI was similar in WT and P2X-dblKO mice. Together, these results suggest that P2X-dblKO mice can form preferences based on postingestive cues and that postingestive detection of MSG does not rely on the same purinergic signaling that is crucial for taste.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.