ArticleThe Journal of general virology2011
prM-antibody renders immature West Nile virus infectious in vivo.
Article in The Journal of general virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- An ultrapotent human antibody neutralizes all maturation states of Zika virus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Article
- Zika virus: mapping and reprogramming the entry.Cell communication and signaling : CCS · 2019Article
- Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus.Nature communications · 2017Article
- A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis.PLoS pathogens · 2017Article
- Structure of the immature Zika virus at 9 Å resolution.Nature structural & molecular biology · 2017Article
- A Single Amino Acid Substitution in the M Protein Attenuates Japanese Encephalitis Virus in Mammalian Hosts.Journal of virology · 2015Article
- The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1.PLoS neglected tropical diseases · 2015Article
- Comprehensive mapping infection-enhancing epitopes of dengue pr protein using polyclonal antibody against prM.Applied microbiology and biotechnology · 2015Article
- Generation and characterization of a monoclonal antibody against prM protein of West Nile virus.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2014Article
- Structural proteins of West Nile virus are a major determinant of infectious particle production and fitness in astrocytes.The Journal of general virology · 2014Article
- Review
- Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN.PloS one · 2014Article
- West nile virus.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2013Article
- A single amino acid substitution in the core protein of West Nile virus increases resistance to acidotropic compounds.PloS one · 2013Article
- Characterization of the mouse neuroinvasiveness of selected European strains of West Nile virus.PloS one · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
West Nile virus (WNV) is a member of the family Flaviviridae and is a neurotropic pathogen responsible for severe human disease. Flavivirus-infected cells release virus particles that contain variable numbers of precursor membrane (prM) protein molecules at the viral surface. Consequently, antibodies are produced against the prM protein. These antibodies have been shown to activate the infectious potential of fully immature flavivirus particles in vitro. Here, we provide in vivo proof that prM antibodies render immature WNV infectious. Infection with antibody-opsonized immature WNV particles caused disease and death of mice, and infectious WNV was found in the brains and sera.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.