ArticleThe Journal of clinical endocrinology and metabolism2011
Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Markers of chronic disease risk in term low birthweight Indian children aged 8-14 years.Frontiers in pediatrics · 2024Article
- Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight.Children (Basel, Switzerland) · 2023Article
- Sex-Dependent Dyslipidemia and Neuro-Humoral Alterations Leading to Further Cardiovascular Risk in Juvenile Obesity.Frontiers in nutrition · 2020Article
- Sex-related change in BMI of 15- to 16-year-old Norwegian girls in cross-sectional studies in 2002 and 2017.BMC pediatrics · 2019Article
- Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides.Scientific reports · 2018Article
- Nutrition and lifestyle in european adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study.Advances in nutrition (Bethesda, Md.) · 2014Review
- Reproductive endocrinology: sex-specific early life effects on metabolism.Nature reviews. Endocrinology · 2011Article
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Authors and funding
18 authors at 12 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to test the hypothesis that a lower birth weight, as an indicator of adverse intrauterine environment, is associated with higher serum leptin levels in European adolescents. We also examined the possible sexual dimorphism in this relationship.
methodsFasting serum leptin was measured in 757 European born at term adolescents (429 females) aged 14.6 ± 1.2 yr. We measured weight and height, and body mass index was calculated. Birth weight, duration of pregnancy, and duration of breast-feeding were obtained from parental records. Duration of pregnancy and breast-feeding, pubertal status, center, body mass index, and physical activity were entered as confounders in the analyses.
resultsThere was a significant interaction effect between sex and birth weight on serum leptin levels (P = 0.044). We observed that body weight at birth was negatively and significantly associated with serum leptin levels only in female adolescents (β = -0.109; adjusted P = 0.008). The association persisted after further controlling for physical activity (β = -0.115; adjusted P = 0.016).
conclusionsThese findings provide further evidence for a sex-specific programming effect of birth weight on serum leptin levels. Our results also contribute to explain the detrimental health effects associated with lower birth weight, such as long-term increased risk of developing obesity and type 2 diabetes.
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