ArticleAmerican journal of physiology. Renal physiology2011
Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- A Vein Attempt? Experimental Models for Arteriovenous Fistula Research.Cardiovascular engineering and technology · 2026Review
- The rodent models of arteriovenous fistula.Frontiers in cardiovascular medicine · 2024Review
- Effect of local anti-vascular endothelial growth factor therapy to prevent the formation of stenosis in outflow vein in arteriovenous fistula.Journal of translational internal medicine · 2021Article
- Targeting Heme Oxygenase-1 in the Arterial Response to Injury and Disease.Antioxidants (Basel, Switzerland) · 2020Review
- A new model of an arteriovenous fistula in chronic kidney disease in the mouse: beneficial effects of upregulated heme oxygenase-1.American journal of physiology. Renal physiology · 2016Article
- A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail.Journal of visualized experiments : JoVE · 2016Article
- Effects of Tongmai oral liquid in femoral ateriovenous fistula.BMC complementary and alternative medicine · 2015Article
- Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo.American journal of physiology. Heart and circulatory physiology · 2015Article
- Novel therapies for hemodialysis vascular access dysfunction: myth or reality?Clinical journal of the American Society of Nephrology : CJASN · 2013Review
- Functioning of an arteriovenous fistula requires heme oxygenase-2.American journal of physiology. Renal physiology · 2013Article
- Vasculature and kidney complications in sickle cell disease.Journal of the American Society of Nephrology : JASN · 2012Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The study of hemodynamic alterations following the creation of an arteriovenous fistula (AVF) is relevant to vascular adaptive responses and hemodialysis access dysfunction. This study examined such alterations in a murine AVF created by anastomosing the carotid artery to the jugular vein. AVF blood flow was markedly increased due to reduced AVF vascular resistance. Despite such markedly increased basal blood flow, AVF blood flow further increased in response to acetylcholine. This AVF model exhibited increased cardiac output and decreased systemic vascular resistance; the kidney, in contrast, exhibited decreased blood flow and increased vascular resistance. Augmentation in AVF blood flow was attended by increased arterial heme oxygenase-1 (HO-1) mRNA and protein expression, the latter localized to smooth muscle cells of the AVF artery; AVF blood flow was substantially reduced in HO-1(-/-) mice compared with HO-1(+/+) mice. Finally, in a murine model of a representative disease known to exhibit impaired hemodynamic responses (sickle cell disease), the creation of an AVF was attended by decreased AVF flow and impaired AVF function. We conclude that this AVF model exhibits markedly increased AVF blood flow, a vasodilatory reserve capacity, increased cardiac output, decreased renal blood flow, and a dependency on intact hemodynamic responses, in general, and HO-1 expression, in particular, in achieving and maintaining AVF blood flow. We suggest that these findings support the utility of this model in investigating the basis for and the consequences of hemodynamic stress, including shear stress, and the pathobiology of hemodialysis AVF dysfunction.
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