ArticleThe Journal of biological chemistry2011
Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Keeping Wavering Bonds: Deactivation-Induced Signaling by Reactive Electrophiles.Biochemistry · 2026Review
- An mTORC2-Lipid Signaling Axis Controls Stress-Induced Organismal Death.Research square · 2026Article
- Free long-chain fatty acids trigger early postembryonic development in starved Caenorhabditis elegans by suppressing mTORC1.PLoS biology · 2024Article
- Application ofInternational journal of molecular sciences · 2023Review
- Global profiling of the proteome, phosphoproteome, and N-glycoproteome of protoscoleces and adult worms ofFrontiers in veterinary science · 2023Article
- Transcriptional effects of electroporation on Echinococcus multilocularis primary cell culture.Parasitology research · 2022Article
- Function of lipid binding proteins of parasitic helminths: still a long road.Parasitology research · 2022Review
- Identification of Prognostic Fatty Acid Metabolism lncRNAs and Potential Molecular Targeting Drugs in Uveal Melanoma.Computational and mathematical methods in medicine · 2022Article
- Lipid metabolism and lipid signals in aging and longevity.Developmental cell · 2021Review
- Molecular mechanisms of fat deposition:Archives animal breeding · 2021Article
- Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5.Oncotarget · 2020Article
- Fatty acid-binding proteins in Echinococcus spp.: the family has grown.Parasitology research · 2020Article
- Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode.Bioscience reports · 2019Article
- Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPARγ.Genes & cancer · 2019Article
- Article
- Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity.Cell chemical biology · 2016Article
- Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans.PLoS genetics · 2014Article
- Article
- ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.Genes & development · 2013Article
- Dietary restriction during development enlarges intestinal and hypodermal lipid droplets in Caenorhabditis elegans.PloS one · 2012Article
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Authors and funding
3 authors.
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Abstract
The lipid-binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work together as functional partners in fat metabolism. In support of this notion, LBP-5 translocated into nuclei, where it appeared to influence C. elegans NHR-49 target genes involved in energy metabolism. Interestingly, LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes. Thus, this knowledge could help identify therapeutic targets to treat obesity and diseases associated with nematode-host interactions.
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