ArticleThe Journal of allergy and clinical immunology2011
Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Environmental assessment and exposure reduction of rodents: a practice parameter.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2012Guideline
- Patterns of Mouse Allergen-Specific IgE and IgG4 in Contemporary Animal Research Environments.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Sex chromosomes and gonadal sex interactions in airway and immune responses to allergen challenge.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Prevalence of indoor air pollutants from First Nation homes in North Central British Columbia, Canada.International journal of circumpolar health · 2024Article
- Biosafety Risk Control Strategies in Laboratory Animal Research.Safety and health at work · 2024Article
- Abundance and Stability as Common Properties of Allergens.Frontiers in allergy · 2021Review
- Predictors for Increased and Reduced Rat and Mouse Allergen Exposure in Laboratory Animal Facilities.Annals of work exposures and health · 2018Article
- Physician-diagnosed eczema is an independent risk factor for incident mouse skin test sensitization in adults.Allergy and asthma proceedings · 2018Article
- Occupational Animal Allergy.Current allergy and asthma reports · 2018Review
- Atopy as a Modifier of the Relationships Between Endotoxin Exposure and Symptoms Among Laboratory Animal Workers.Annals of work exposures and health · 2017Article
- Weighing the evidence: Bias and confounding in epidemiologic studies in allergy/immunology.The Journal of allergy and clinical immunology · 2017Article
- Laboratory Animal Allergy in the Modern Era.Current allergy and asthma reports · 2015Review
- A risk-based approach to reducing exposure of staff to laboratory animal allergens.Lab animal · 2015Review
- Influence of 5 different caging types and the use of cage-changing stations on mouse allergen exposure.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Associations between serum folate and vitamin D levels and incident mouse sensitization in adults.The Journal of allergy and clinical immunology · 2014Article
- Immune responses to inhalant Mammalian allergens.Frontiers in immunology · 2014Review
- Experiences from occupational exposure limits set on aerosols containing allergenic proteins.The Annals of occupational hygiene · 2012Article
- Time for new methods for avoidance of house dust mite and other allergens.Current allergy and asthma reports · 2012Article
- Performance of the halogen immunoassay to assess airborne mouse allergen-containing particles in a laboratory animal facility.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe role of natural aeroallergen exposure in modulating allergen-specific immune responses is not well understood.
objectiveWe sought to examine relationships between mouse allergen exposure and mouse-specific immune responses.
methodsNew employees (n = 179) at a mouse facility underwent repeated assessment of mouse allergen exposure, skin prick tests (SPTs), and measurement of mouse-specific IgG levels. Relationships between the mean level of exposure, variability of exposure (calculated as log deviation), and time to development of immunologic outcomes were examined by using Cox proportional hazards models.
resultsBy 24 months, 32 (23%) participants had experienced a positive SPT response, and 10 (8%) had mouse-specific IgG₄. The incidence of a positive SPT response increased as levels of exposure increased from low to moderate, peaking at 1.2 ng/m³, and decreased beyond this point (P = .04). The more variable the exposure was across visits, the lower the incidence of a positive SPT response (hazard ratio [HR], 0.17; 95% CI, 0.07-0.41). Variability of exposure was an independent predictor of a positive SPT response in a model that included both exposure metrics. In contrast, the incidence of mouse-specific IgG₄ increased with increasing levels of mouse allergen exposure (HR, 2.9; 95% CI, 1.4-6.0), and there was evidence of a higher risk of mouse-specific IgG₄ with greater variability of exposure (HR, 6.3; 95% CI, 0.4-95.2).
conclusionBoth the level and variability of mouse allergen exposure influence the humoral immune response, with specific patterns of exposure associated with specific immunophenotypes. Exposure variability might be a more important predictor of a positive SPT response, whereas the average exposure level might be a more important predictor of mouse-specific IgG₄.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.