ArticleNeuropathology and applied neurobiology2012
S100β as a novel and accessible indicator for the presence of monocyte-driven encephalitis in AIDS.
Article in Neuropathology and applied neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis.Journal of neurovirology · 2019Article
- The flavivirus dengue induces hypertrophy of white matter astrocytes.Journal of neurovirology · 2016Article
- Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques.Brain, behavior, and immunity · 2015Article
- Form follows function: astrocyte morphology and immune dysfunction in SIV neuroAIDS.Journal of neurovirology · 2014Article
- Microglia activation by SIV-infected macrophages: alterations in morphology and cytokine secretion.Journal of neurovirology · 2012Article
- An inverted blood-brain barrier model that permits interactions between glia and inflammatory stimuli.Journal of neuroscience methods · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
aimsThe pathogenesis of human/simian immunodeficiency virus encephalitis (HIVE/SIVE) remains incompletely understood, but is associated with alterations in the blood-brain barrier. At present, it is not possible to easily determine if an individual has HIVE/SIVE before post mortem examination.
methodsWe have examined serum levels of the astroglial protein S100β in SIV-infected macaques and show that it can be used to determine which animals have SIVE. We also checked for correlations with inflammatory markers such as CCL2/MCP-1, IL-6 and C-reactive protein.
resultsWe found that increased S100β protein in serum correlated with decreased expression of the tight junction protein zonula occludens-1 on brain microvessels. Furthermore, the decrease in zonula occludens-1 expression was spatially related to SIVE lesions and perivascular deposition of plasma fibrinogen. There was no correlation between encephalitis and plasma levels of IL-6, MCP-1/CCL2 or C-reactive protein.
conclusionsTogether, these data indicate that SIVE lesions are associated with vascular leakage that can be determined by S100β protein in the periphery. The ability to simply monitor the presence of SIVE will greatly facilitate studies of the neuropathogenesis of AIDS.
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