Evidence map›Paper›PMID 21696339›Full record

ArticleInternational journal of radiation biology2011

Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation.

Benjamin B Williams, Ruhong Dong, Roberto J Nicolalde, Thomas P Matthews, David J Gladstone, Eugene Demidenko, Bassem I Zaki, Ildar K Salikhov, Piotr N Lesniewski, Harold M Swartz

Abstract readEvaluation Study
In one paragraph

Article in International journal of radiation biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

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  10. Imaging tooth enamel using zero echo time (ZTE) magnetic resonance imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Benjamin B WilliamsDepartment of Diagnostic Radiology, Dartmouth Physically-based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA. Benjamin.B.Williams@dartmouth.edu
Ruhong Dong
Roberto J Nicolalde
Thomas P Matthews
David J Gladstone
Eugene Demidenko
Bassem I Zaki
Ildar K Salikhov
Piotr N Lesniewski
Harold M Swartz
Dartmouth College · USDartmouth–Hitchcock Medical Center · US

Funding

Pulmonary response to external and internal exposure: model for dispersion eventU19AI067733 · NIAID · UNIVERSITY OF ROCHESTER · PI THURSTON, SALLY W · 2005 to 2009
$20.8M
Scientific and Administrative Core: Dartmouth Medical SchoolU19AI091173 · NIAID · DARTMOUTH COLLEGE · PI SWARTS, STEVEN GREGORY · 2010 to 2014
$16.3M
Development of In Vivo EPR Tooth Dosimetry for Use by Non-Expert PersonnelR43AI081495 · NIAID · CLIN-EPR, LLC · PI GRINBERG, OLEG · 2009 to 2010
$600k
NIAID NIH HHS R43 AI081495NIAID NIH HHS R43-AI-081495NIAID NIH HHS U19-AI-06773NIAID NIH HHS U19 AI067733NIAID NIH HHS U19 AI091173NIAID NIH HHS U19-AI-91173
6 · The paper itself

Abstract

purposeThe ability to estimate individual exposures to radiation following a large attack or incident has been identified as a necessity for rational and effective emergency medical response. In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel has been developed to meet this need. MATERIALS AND

methodsA novel transportable EPR spectrometer, developed to facilitate tooth dosimetry in an emergency response setting, was used to measure upper incisors in a model system, in unirradiated subjects, and in patients who had received total body doses of 2 Gy.

resultsA linear dose response was observed in the model system. A statistically significant increase in the intensity of the radiation-induced EPR signal was observed in irradiated versus unirradiated subjects, with an estimated standard error of dose prediction of 0.9 ± 0.3 Gy.

conclusionsThese results demonstrate the current ability of in vivo EPR tooth dosimetry to distinguish between subjects who have not been irradiated and those who have received exposures that place them at risk for acute radiation syndrome. Procedural and technical developments to further increase the precision of dose estimation and ensure reliable operation in the emergency setting are underway. With these developments EPR tooth dosimetry is likely to be a valuable resource for triage following potential radiation exposure of a large population.

Indexed as

Radioactive Hazard ReleaseBiological AssayEquipment DesignEquipment Failure AnalysisHumansRadiation InjuriesRadiation MonitoringRadioisotopesToothWhole-Body IrradiationRadioisotopes

Identifiers

PMID21696339
PMCPMC4086327
OpenAlexW2162859268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.