ArticleJournal of the American Chemical Society2011
An advance in proline ligation.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 115 citations in OpenAlex.
- Native Chemical Ligation to Install Chemical Protein Modifications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity.Nature chemistry · 2021Article
- Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction.Journal of the American Chemical Society · 2020Article
- Chemical biology of glycoproteins: From chemical synthesis to biological impact.Methods in enzymology · 2019Article
- Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations.Chemical science · 2018Article
- Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.Organic letters · 2017Article
- A molecular engineering toolbox for the structural biologist.Quarterly reviews of biophysics · 2017Review
- Insights into the deselenization of selenocysteine into alanine and serine.Chemical science · 2015Article
- Total synthesis of glycosylated proteins.Topics in current chemistry · 2015Review
- The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.Angewandte Chemie (International ed. in English) · 2013Review
- Proline editing: a general and practical approach to the synthesis of functionally and structurally diverse peptides. Analysis of steric versus stereoelectronic effects of 4-substituted prolines on conformation within peptides.Journal of the American Chemical Society · 2013Article
- Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141).Angewandte Chemie (International ed. in English) · 2012Article
- At last: erythropoietin as a single glycoform.Angewandte Chemie (International ed. in English) · 2012Article
- Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.Journal of the American Chemical Society · 2012Article
- Advances in proline ligation.Journal of the American Chemical Society · 2012Article
- Probing the frontiers of glycoprotein synthesis: the fully elaborated β-subunit of the human follicle-stimulating hormone.Angewandte Chemie (International ed. in English) · 2012Article
- Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain.Israel journal of chemistry · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Native chemical ligation (NCL) is widely applicable for building proteins in the laboratory. Since the discovery of this method, many strategies have been developed to enhance its capability and efficiency. Because of the poor reactivity of proline thioesters, ligation at a C-terminal proline site is not readily accomplished. Here, we demonstrate that ligation at an N-terminal protein is feasible using the combined logic of NCL and metal-free dethiylation (MFD).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.