ReviewBioconjugate chemistry2011
64Cu-labeled phosphonium cations as PET radiotracers for tumor imaging.
Review in Bioconjugate chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- A prospective study to compare the diagnostic accuracy ofJournal of cancer research and clinical oncology · 2024Article
- The Preparation and Execution of Exploratory Human Studies on NovelACS pharmacology & translational science · 2023Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy.International journal of molecular sciences · 2021Article
- Synthesis and Biological Evaluation ofMolecules (Basel, Switzerland) · 2021Article
- Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [Theranostics · 2021Article
- Emerging Tracers for Nuclear Cardiac PET Imaging.Nuclear medicine and molecular imaging · 2018Review
- Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.Chemical reviews · 2017Review
- Heteromer Nanostars by Spontaneous Self-Assembly.Nanomaterials (Basel, Switzerland) · 2017Article
- Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents.Nuclear medicine and molecular imaging · 2016Review
- Alternative chromatographic system for the quality control of lipophilic technetium-99m radiopharmaceuticals such as [(99m)Tc(MIBI)₆].Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors.Cancer medicine · 2014Article
- Optical imaging of tumors with copper-labeled rhodamine derivatives by targeting mitochondria.Theranostics · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alteration in mitochondrial transmembrane potential (ΔΨ(m)) is an important characteristic of cancer. The observation that the enhanced negative mitochondrial potential is prevalent in tumor cell phenotype provides a conceptual basis for development of mitochondrion-targeting therapeutic drugs and molecular imaging probes. Since plasma and mitochondrial potentials are negative, many delocalized organic cations, such as rhodamine-123 and (3)H-tetraphenylphosphonium, are electrophoretically driven through these membranes, and able to localize in the energized mitochondria of tumor cells. Cationic radiotracers, such as (99m)Tc-Sestamibi and (99m)Tc-Tetrofosmin, have been clinically used for diagnosis of cancer by single photon emission computed tomography (SPECT) and noninvasive monitoring of the multidrug resistance (MDR) transport function in tumors of different origin. However, their diagnostic and prognostic values are often limited due to their insufficient tumor localization (low radiotracer tumor uptake) and high radioactivity accumulation in the chest and abdominal regions (low tumor selectivity). In contrast, the (64)Cu-labeled phosphonium cations represent a new class of PET (positron emission tomography) radiotracers with good tumor uptake and high tumor selectivity. This review article will focus on our recent experiences in evaluation of (64)Cu-labeled phosphonium cations as potential PET radiotracers. The main objective is to illustrate the impact of radiometal chelate on physical, chemical, and biological properties of (64)Cu radiotracers. It will also discuss some important issues related to their tumor selectivity and possible tumor localization mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.