Evidence map›Paper›PMID 21696137›Full record

ArticleACS nano2011

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins.

Brett R Goldsmith, Joseph J Mitala, Jesusa Josue, Ana Castro, Mitchell B Lerner, Timothy H Bayburt, Samuel M Khamis, Ryan A Jones, Joseph G Brand, Stephen G Sligar and 5 more

Abstract read
In one paragraph

Article in ACS nano, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Artificial Olfactory Biohybrid System: An Evolving Sense of Smell.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Carbon Nanotube Chemical Sensors.Chemical reviews · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Brett R GoldsmithDepartment of Physics & Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Joseph J Mitala
Jesusa Josue
Ana Castro
Mitchell B Lerner
Timothy H Bayburt
Samuel M Khamis
Ryan A Jones
Joseph G Brand
Stephen G Sligar
Charles W Luetje
Alan Gelperin
Paul A Rhodes
Bohdana M Discher
A T Charlie Johnson

Funding

Ligand Recognition Among Mammalian Odorant ReceptorsR01DC008119 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LUETJE, CHARLES WARD · 2008 to 2010
$972k
NIDCD NIH HHS R01 DC008119
6 · The paper itself

Abstract

We have designed and implemented a practical nanoelectronic interface to G-protein coupled receptors (GPCRs), a large family of membrane proteins whose roles in the detection of molecules outside eukaryotic cells make them important pharmaceutical targets. Specifically, we have coupled olfactory receptor proteins (ORs) with carbon nanotube transistors. The resulting devices transduce signals associated with odorant binding to ORs in the gas phase under ambient conditions and show responses that are in excellent agreement with results from established assays for OR-ligand binding. The work represents significant progress on a path toward a bioelectronic nose that can be directly compared to biological olfactory systems as well as a general method for the study of GPCR function in multiple domains using electronic readout.

Indexed as

Electrical Equipment and SuppliesAnimalsBiomimeticsBiosensing TechniquesHEK293 CellsHumansMiceNanotechnologyNanotubes, CarbonReceptors, OdorantTransistors, ElectronicNanotubes, CarbonReceptors, Odorant

Identifiers

PMID21696137
PMCPMC4165341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.