ArticleClinical rheumatology2012
Assessment of biocorrelates for brain involvement in female patients with rheumatoid arthritis.
Article in Clinical rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Pathogenic Drivers of Difficult-to-Treat Rheumatoid Arthritis: Synovium and Beyond.International journal of molecular sciences · 2026Review
- A comparative retrospective longitudinal study of arthritis risk and cognitive decline in older adults.Scientific reports · 2024Article
- The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases.Fundamental research · 2024Review
- Causality between rheumatoid arthritis and the risk of cognitive impairment: a Mendelian randomization study.Arthritis research & therapy · 2024Article
- Longitudinal Study of Cognitive Functioning in Adults with Juvenile Idiopathic Arthritis.Biomedicines · 2022Article
- Cognitive Decline in Rheumatoid Arthritis: Insight into the Molecular Pathogenetic Mechanisms.International journal of molecular sciences · 2021Review
- The interplay between immunosenescence and age-related diseases.Seminars in immunopathology · 2020Review
- Article
- The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside.Frontiers in medicine · 2020Review
- Neuronal Correlates of Cognitive Control Are Altered in Women With Endometriosis and Chronic Pelvic Pain.Frontiers in systems neuroscience · 2020Article
- Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.Immunity & ageing : I & A · 2020Review
- Fatigue in IBD: epidemiology, pathophysiology and management.Nature reviews. Gastroenterology & hepatology · 2019Review
- S100 proteins in rheumatic diseases.Nature reviews. Rheumatology · 2018Review
- Proteomic analysis of plasma from rheumatoid arthritis patients with mild cognitive impairment.Clinical rheumatology · 2018Article
- Cognitive impairment in rheumatoid arthritis: role of lymphocyte subsets, cytokines and neurotrophic factors.Clinical rheumatology · 2018Article
- Gulf War illness (GWI) as a neuroimmune disease.Experimental brain research · 2017Article
- Autoantibodies against myelin sheath and S100β are associated with cognitive dysfunction in patients with rheumatoid arthritis.Clinical rheumatology · 2017Article
- Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue.World journal of gastroenterology · 2017Article
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- Variant of multiple sclerosis with dementia and tumefactive demyelinating brain lesions.World journal of clinical cases · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) abnormalities are rare in patients with rheumatoid arthritis (RA). Direct studies done to investigate brain involvement in RA are few or even absent. We hypothesized that CNS is not excluded from the inflammatory disease process in RA. Thus we systematically investigated markers of brain involvement in 55 females with RA. We examined patients' cognition using battery of sensitive psychometric testing [Mini-Mental State Examination, Stanford-Binet test (fourth edition) and Wechsler Memory Scale-Revised] and by recording P300 component of event-related potentials, a neurophysiological analogue. We also measured the serum levels of S100B and neuron-specific enolase (NSE), markers of glial and neuronal cells. Compared to control subjects, lower scores in cognitive testing were reported in 71% of the patients (n=39) and abnormal P300 latency and amplitude (P<0.001, 0.050). Patients had higher levels of S100B (P<0.029) and higher levels of S100B were correlated with lower total scores of cognitive functions (P<0.01), P300 latency (P<0.05), and NSE concentrations (P<0.01). However, cognitive scores did not correlate with disease activity or severity. Although depression scores were significant in patients with RA (P<0.001), but they did not correlate with cognitive scores. Seven patients had white matter hyperintensities in MRI brain suggesting vasculitis, ischemic brain lesions and dots of demyelination, and all had higher levels of S100B. Results of this study directly indicate that the disease process (inflammation and demyelination) is associated with cognitive deficits observed with RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.