ArticleSurgical endoscopy2011
Pepsin detection in patients with laryngopharyngeal reflux before and after fundoplication.
Article in Surgical endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03463395 (Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux
Who cites it
11 citing papers in PubMed, 52 citations in OpenAlex.
- First agreement analysis and day-to-day comparison of pharyngeal pH monitoring with pH/impedance monitoring in patients with suspected laryngopharyngeal reflux.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Trial
- Laryngopharyngeal reflux: is laparoscopic fundoplication an effective treatment?Annals of the Royal College of Surgeons of England · 2022Review
- Magnetic sphincter augmentation is an effective treatment for atypical symptoms caused by gastroesophageal reflux disease.Surgical endoscopy · 2020Article
- Optimization of Saliva Collection and Immunochromatographic Detection of Salivary Pepsin for Point-of-Care Testing of Laryngopharyngeal Reflux.Sensors (Basel, Switzerland) · 2020Article
- Sep70/Pepsin expression in hypopharynx combined with hypopharyngeal multichannel intraluminal impedance increases diagnostic sensitivity of laryngopharyngeal reflux.Surgical endoscopy · 2018Article
- Reflux and Voice Disorders: Have We Established Causality?Current otorhinolaryngology reports · 2016Article
- How to Approach Laryngopharyngeal Reflux: An Otolaryngology Perspective.Current gastroenterology reports · 2016Review
- Article
- Hypopharyngeal pepsin and Sep70 as diagnostic markers of laryngopharyngeal reflux: preliminary study.Surgical endoscopy · 2015Article
- Intraesophageal pressure recording improves the detection of cough during multichannel intraluminal impedance testing in children.Journal of pediatric gastroenterology and nutrition · 2014Article
- Impact of laparoscopic fundoplication for the treatment of laryngopharyngeal reflux: review of the literature.International journal of otolaryngology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome patients with gastroesophageal reflux disease (GERD) suffer from laryngopharyngeal reflux (LPR). There is no reliable diagnostic test for LPR as there is for GERD. We hypothesized that detection of pepsin (a molecule only made in the stomach) in laryngeal epithelium or sputum should provide evidence for reflux of gastric contents to the larynx, and be diagnostic of LPR. We tested this hypothesis in a prospective study in patients with LPR symptoms undergoing antireflux surgery (ARS).
methodsNine patients undergoing ARS for LPR symptoms were studied pre- and postoperatively using a clinical symptom questionnaire, laryngoscopy, 24-h pH monitoring, biopsy of posterior laryngeal mucosa, and sputum collection for pepsin Western blot assay.
resultsThe primary presenting LPR symptom was hoarseness in six, cough in two, and globus sensation in one patient. Pepsin was detected in the laryngeal mucosa in eight of nine patients preoperatively. There was correlation between biopsy and sputum (+/+ or -/-) in four of five patients, both analyzed preoperatively. Postoperatively, pH monitoring improved in all but one patient and normalized in five of eight patients. Eight of nine patients reported improvement in their primary LPR symptom (six good, two mild). Only one patient (who had negative preoperative pepsin) reported no response to treatment of the primary LPR symptom. Postoperatively, pepsin was detected in only one patient.
conclusionsPepsin is often found on laryngeal epithelial biopsy and in sputum of patients with pH-test-proven GERD and symptoms of LPR. ARS improves symptoms and clears pepsin from the upper airway. Detection of pepsin improves diagnostic accuracy in patients with LPR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.