ReviewCurrent rheumatology reports2011
Familial Mediterranean fever and seronegative arthritis.
Review in Current rheumatology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Increased group 2 Innate lymphoid cell (ILC2) activity in pediatric familial mediterranean fever patients with spondyloarthropathy.Clinical and experimental medicine · 2026Article
- Familial mediterranean fever in a patient with ankylosing spondylitis: could familial mediterranean fever explain a typical eight-year ankylosing spondylitis?Rheumatology international · 2024Review
- Mevalonate kinase gene polymorphisms in ankylosing spondylitis patients: A cross-sectional study.Archives of rheumatology · 2023Article
- Spondyloarthritis in familial Mediterranean fever: a cohort study.Rheumatology international · 2022Article
- Pyoderma gangrenosum in a patient with familial Mediterranean fever and chronic inflammatory seronegative arthropathy: a unique triad.BMJ case reports · 2022Article
- Sacroiliitis in children and adolescents with familial Mediterranean fever.Advances in rheumatology (London, England) · 2021Article
- Enthesitis may be one of the signs of severe disease in familial Mediterranean fever.Clinical rheumatology · 2021Article
- Evaluation of the thicknesses of cartilage and enthesis in familial Mediterranean fever and enthesitis-related arthritis.Northern clinics of Istanbul · 2020Article
- The musculoskeletal system manifestations in children with familial Mediterranean fever.Northern clinics of Istanbul · 2020Article
- Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis.PLoS genetics · 2019Article
- Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy.PloS one · 2018Article
- Autoinflammatory Diseases and Physical Therapy.Mediterranean journal of rheumatology · 2017Review
- The Frequency of Ankylosing Spondylitis Among Patients With Familial Mediterranean Fever and the Relationship With M694V Mutation.Archives of rheumatology · 2016Article
- Clinical and Genetic Features of Korean Patients with Recurrent Fever and Multi-System Inflammation without Infectious or Autoimmune Evidence.Journal of Korean medical science · 2016Article
- Familial Mediterranean fever: An updated review.European journal of rheumatology · 2014Review
- Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever?Clinical rheumatology · 2013Article
- Enthesopathy in patients with familial Mediterranean fever: increased prevalence in M694 V variant.Rheumatology international · 2013Article
- MEFV gene mutations in Turkish children with juvenile idiopathic arthritis.European journal of pediatrics · 2013Article
- Bloody Diarrhea as a Presentation Manifestation of Familial Mediterranean Fever in a Patient with Compound Heterozygote Mutations of the MEFV Gene.Gut and liver · 2013Article
- High prevalence of spondyloarthritis and ankylosing spondylitis among familial Mediterranean fever patients and their first-degree relatives: further evidence for the connection.Arthritis research & therapy · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial Mediterranean fever (FMF) is characterized by recurrent, self-limited episodes of polyserositis, with articular involvement also being a common manifestation. The pattern and joint predilection of arthritis show many similarities to those of spondyloarthritis. Moreover, case series suggest an increased prevalence of ankylosing spondylitis or spondyloarthritis among FMF patients. FMF is caused by mutations in the MEFV gene encoding pyrin, which is believed to be involved in regulation of interelukin-1β activation. Recent studies conducted in populations with a high background carrier rate of MEFV variants have reported an increased frequency of M694V among AS patients with no personal or family history of FMF. These findings are of interest, as both candidate gene and genome-wide association studies suggest that the interleukin-1 cytokine pathway may be implicated in the pathogenesis of ankylosing spondylitis. Therefore, association of M694V with ankylosing spondylitis can be recognized as a geographic region-specific risk factor affecting a common inflammatory pathway in the disease pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.