Trial reportPediatric nephrology (Berlin, Germany)2011
Early steroid withdrawal in pediatric renal transplant: five years of follow-up.
Trial report in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Corticosteroid Use and Growth After Pediatric Solid Organ Transplantation: A Systematic Review and Meta-Analysis.Transplantation · 2017Pooled it
- Astragalus Extract Mixture HT042 Alleviates Dexamethasone-Induced Bone Growth Retardation in Rat Metatarsal Bones.Nutrients · 2024Article
- Bone Disease in CKD in Children.Calcified tissue international · 2021Review
- Strategies for Optimizing Growth in Children With Chronic Kidney Disease.Frontiers in pediatrics · 2020Review
- A Review of Induction with Rabbit Antithymocyte Globulin in Pediatric Heart Transplant Recipients.Annals of transplantation · 2018Review
- Kidney transplantation fails to provide adequate growth in children with chronic kidney disease born small for gestational age.Pediatric nephrology (Berlin, Germany) · 2017Observational
- Biologics in renal transplantation.Pediatric nephrology (Berlin, Germany) · 2015Review
- Final adult height in kidney recipients who underwent highly successful transplantation as children: a single-center experience.Clinical and experimental nephrology · 2014Article
- Long-term outcomes of children after solid organ transplantation.Clinics (Sao Paulo, Brazil) · 2014Review
- Steroid withdrawal in renal transplantation.Pediatric nephrology (Berlin, Germany) · 2013Review
- Post transplant lymphoproliferative disorders: risk, classification, and therapeutic recommendations.Current treatment options in oncology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This prospective, comparative trial investigated the impact on mean change in height standard deviation score (SDS), acute rejection rate, and renal function of early steroid withdrawal in 96 recipients with 5 years of follow-up. Recipients under basiliximab induction and steroid withdrawal (SW: TAC/MMF; n = 55) were compared with a matched steroid control group (SC: TAC/MMF/STEROID, n = 41). SW received steroids until Day 6, SC decreased to 10 mg/m(2) within 2 months post-transplant. Five years after SW, the longitudinal growth (SDS) gain was 1.4 ± 0.4 vs. 1.1 ± 0.3 for SC group (p < 0.02). Height benefits in prepubertal and pubertal status in both groups were demonstrated in the delta growth trends (mixed model; p < 0.01). Biopsy-proven acute rejection in SW was 11% and 17.5%, SC (p: ns). Mean eGFR (ml/min/1.73 m(2)) at 5 years post-transplant was SW 80.6 ± 27.8 vs. 82.6 ± 25.1 for SC (p: ns). The death-censored graft survival rate at 1 and 5 years was 99 and 90% for SW; 98 and 96% for SC (p = ns). PTLD incidence in SW 3.3 vs. 2.5% in SC (p: ns). Five years post-transplant, early steroid withdrawal showed positive impacts on growth, stable renal function without increased acute rejection risk, and PTLD incidence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.