ReviewClinical and experimental nephrology2011
The pathogenesis and treatment of pediatric Henoch-Schönlein purpura nephritis.
Review in Clinical and experimental nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- Correlation between the course of kidney injury and clinicopathology and prognosis of children with Henoch-Schönlein purpura nephritis.International urology and nephrology · 2025Article
- Efficacy and Long-Term Outcomes of Tacrolimus versus Cyclophosphamide and Mycophenolate Mofetil in the Management of Pediatric IgA Vasculitis Nephritis: A Cohort Study in Single-Center.Drug design, development and therapy · 2025Article
- Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis.International journal of molecular sciences · 2024Article
- Regulatory T and B cells in pediatric Henoch-Schönlein purpura: friends or foes?Arthritis research & therapy · 2024Article
- Bibliometric Analysis of Research Relating to IgA Nephropathy from 2010 to 2021.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Individualized medication based on pharmacogenomics and treatment progress in children with IgAV nephritis.Frontiers in pharmacology · 2022Review
- Imbalanced Th17/Treg in peripheral blood of adult patients with immunoglobulin A vasculitis nephritis.Central-European journal of immunology · 2021Article
- Metagenomic profiling reveals dominance of gram-positive bacteria in the gut microbiome shifts associated with immunoglobulin A vasculitis (Henoch-Schönlein Purpura).Clinical & translational immunology · 2021Article
- Association between Tfh and PGA in children with Henoch-Schönlein purpura.Open medicine (Warsaw, Poland) · 2021Article
- [Expression and significance of follicular helper T cells and galactose-deficient IgA1 in children with Henoch-Schönlein purpura].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis.Kidney international reports · 2019Article
- Association between anti-α-1,4-D-polygalacturonic acid antibodies and Henoch-Schönlein purpura in children.The Journal of international medical research · 2019Observational
- Acute renal insufficiency and pancreatitis in a child with atypical Henoch-Schönlein purpura: efficacy of a single dose of cyclophosphamide.The Journal of international medical research · 2018Article
- Correlation between Traditional Chinese Medicine Symptom Patterns and the Renal Function, Immunologic Function Index, and Blood Coagulation Index in Patients with Henoch-Schönlein Purpura Nephritis.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- The incidence and severity of IgA vasculitis with nephritis over a 10-year period in our hospital.Fukushima journal of medical science · 2017Article
- Application value of laboratory indexes in the differential diagnosis of Henoch-Schoenlein purpura.Zeitschrift fur Rheumatologie · 2017Article
- [Comparison of age-based clinical and abnormal immune parameters in patients with Henoch-Schönlein purpura].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- Anaphylactoid Purpura Associated with Streptococcal Cellulitis: A Case Report and Literature Review.Case reports in medicine · 2017Article
- Treatment of Henoch Schonlein nephritis; new trends.Journal of nephropathology · 2016Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. Thus, it is important to clarify the onset mechanism of Henoch-Schönlein purpura nephritis (HSPN) and to identify the most appropriate treatment. We herein review the pathogenesis and treatment of HSPN. As to the pathogenesis, several studies suggest that galactose-deficient IgA1 is recognized by anti-glycan antibodies, leading to the formation of circulating immune complexes and their mesangial deposition, thereby inducing renal injury. Aggressive therapies for the treatment of severe HSPN, including multiple drug combination therapy and plasmapheresis, have been shown to be effective in ameliorating proteinuria and histological severity. Nevertheless, detailed investigations of the pathogenesis of HSPN and double-blind randomized control studies on children with HSPN are still necessary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.