ReviewReviews in endocrine & metabolic disorders2011
Hypothalamic control of energy and glucose metabolism.
Review in Reviews in endocrine & metabolic disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03540758 (Regulation of Endogenous Glucose Production by Central KATP Channels), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regulation of Endogenous Glucose Production by Central KATP Channels
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of cafeteria diet and caloric restriction on pituitary hormones and metabolic phenotype in male Wistar rats.Endocrine · 2025Article
- Intrauterine growth restriction (IUGR) modifies the hypothalamic response to a systemic glucose load in adult male rats, as assessed by proteomic analysis.Metabolic brain disease · 2025Article
- Central Downregulation of S-Resistin Alleviates Inflammation in EWAT and Liver and Prevents Adipocyte Hypertrophy.Journal of the Endocrine Society · 2025Article
- Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling.Theranostics · 2024Article
- Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.Biology of sex differences · 2023Article
- Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Paraventricular Vitamin D Receptors Are Required for Glucose Tolerance in Males but Not Females.Frontiers in endocrinology · 2022Article
- Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.Cell death & disease · 2021Article
- Characterization of mWake expression in the murine brain.The Journal of comparative neurology · 2021Article
- Metabolic Consequences of Neuronal HIF1α-Deficiency in Mediobasal Hypothalamus in Mice.Frontiers in endocrinology · 2021Article
- p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.Nature communications · 2018Article
- Hypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation.Scientific reports · 2016Article
- Article
- Brain GLP-1 and insulin sensitivity.Molecular and cellular endocrinology · 2015Review
- Can Brown Fat Win the Battle Against White Fat?Journal of cellular physiology · 2015Review
- S-resistin, a non secretable resistin isoform, impairs the insulin signalling pathway in 3T3-L1 adipocytes.Journal of physiology and biochemistry · 2015Article
- A potential role for the midbrain in integrating fat-free mass determined energy needs: An H2 (15) O PET study.Human brain mapping · 2015Article
- Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.Peptides · 2014Article
- Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.Cell · 2013Article
- GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.Diabetologia · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The central nervous system (CNS), generally accepted to regulate energy homeostasis, has been implicated in the metabolic perturbations that either cause or are associated with obesity. Normally, the CNS receives hormonal, metabolic, and neuronal input to assure adequate energy levels and maintain stable energy homeostasis. Recent evidence also supports that the CNS uses these same inputs to regulate glucose homeostasis and this aspect of CNS regulation also becomes impaired in the face of dietary-induced obesity. This review focuses on the literature surrounding hypothalamic regulation of energy and glucose homeostasis and discusses how dysregulation of this system may contribute to obesity and T2DM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.