SynthesisInternational journal of colorectal disease2011
Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.
Synthesis in International journal of colorectal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between the hOGG1 1245C>G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analysis Based on 7010 Cases and 10,674 Controls.Journal of gastrointestinal cancer · 2021Pooled it
- Association of OGG1 Ser326Cys polymorphism and pancreatic cancer susceptibility: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Integrating next-generation sequencing and artificial intelligence for the identification and validation of pathogenic variants in colorectal cancer.Frontiers in oncology · 2025Article
- 8-Oxoguanine DNA Glycosylase 1 Upregulation as a Risk Factor for Obesity and Colorectal Cancer.International journal of molecular sciences · 2023Article
- Article
- Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients.International journal of molecular sciences · 2020Review
- XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Gene Polymorphisms and Colorectal Cancer Risk: A Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2017Article
- The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2017Article
- Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan.World journal of gastroenterology · 2016Article
- Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer.Journal of Cancer · 2016Review
- Association between OGG1 Ser326Cys polymorphism and risk of upper aero-digestive tract and gastrointestinal cancers: a meta-analysis.SpringerPlus · 2016Review
- Article
- Genetic association between hOGG1 C8069G polymorphism and colorectal cancer risk.International journal of clinical and experimental medicine · 2015Article
- APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans.World journal of gastroenterology · 2014Article
- Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.Journal of epidemiology · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case-control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory. MATERIALS AND
methodsThis meta-analysis enrolled 12 studies to estimate the overall risk of OGG1 Ser326Cys polymorphism associated with CRC. The pooled odds ratios (ORs) were performed for codominant model (Cys/Cys versus Ser/Ser; Ser/Cys versus Ser/Ser), dominant model (Ser/Cys + Cys/Cys versus Ser/Ser) and recessive model (Cys/Cys versus Ser/Cys + Ser/Ser).
resultsNo significant associations were found for Cys/Cys versus Ser/Ser (OR = 1.19, 95% confidence interval (CI) 0.92-1.53), Ser/Cys versus Ser/Ser (OR = 1.04, 95% CI 0.95-1.13), Ser/Cys + Cys/Cys versus Ser/Ser (OR = 1.06, 95% CI 0.98-1.16) and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.11, 95% CI 0.90-1.38); moreover, in the stratified analyses, no significantly increased risk was found for all genetic models.
conclusionsOur meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.
Indexed as
Identifiers
21695387What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.