ArticlePLoS pathogens2011
Bacteria-Induced Dscam Isoforms of the Crustacean, Pacifastacus leniusculus.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 102 citations in OpenAlex.
- Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus.Viruses · 2022Review
- Transcriptomic Profile of the CockleToxins · 2021Article
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- Exploring the molecular basis of adaptive evolution in hydrothermal vent crab Austinograea alayseae by transcriptome analysis.PloS one · 2017Article
- Article
- A C-type lectin with an immunoglobulin-like domain promotes phagocytosis of hemocytes in crayfish Procambarus clarkii.Scientific reports · 2016Article
- Retraction: Bacteria-Induced Dscam Isoforms of the Crustacean, Pacifastacus leniusculus.PLoS pathogens · 2016Article
- Down syndrome cell adhesion molecule 1: testing for a role in insect immunity, behaviour and reproduction.Royal Society open science · 2016Article
- Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system.Scientific reports · 2016Article
- Long-range RNA pairings contribute to mutually exclusive splicing.RNA (New York, N.Y.) · 2016Article
- High Innate Immune Specificity through Diversified C-Type Lectin-Like Domain Proteins in Invertebrates.Journal of innate immunity · 2016Article
- A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata.Developmental and comparative immunology · 2015Article
- Novel transcriptome assembly and improved annotation of the whiteleg shrimp (Litopenaeus vannamei), a dominant crustacean in global seafood mariculture.Scientific reports · 2014Article
- Hijacking of host calreticulin is required for the white spot syndrome virus replication cycle.Journal of virology · 2014Article
- Genetic dissection of Anopheles gambiae gut epithelial responses to Serratia marcescens.PLoS pathogens · 2014Article
- C-type lectin binds to β-integrin to promote hemocytic phagocytosis in an invertebrate.The Journal of biological chemistry · 2014Article
- Quantitative profiling of Drosophila melanogaster Dscam1 isoforms reveals no changes in splicing after bacterial exposure.PloS one · 2014Article
- Characterization of a novel hemolytic activity of human IgG fractions arising from diversity in protein and oligosaccharide components.PloS one · 2014Article
- Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.The EMBO journal · 2013Article
- Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting.Nature neuroscience · 2013Article
Corrections and comments
- Retraction · 2016-05-04Concerns/Issues about Image · Investigation by Company/Institution · Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Removed ·
- Retracted
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Down syndrome cell adhesion molecule, also known as Dscam, is a member of the immunoglobulin super family. Dscam plays an essential function in neuronal wiring and appears to be involved in innate immune reactions in insects. The deduced amino acid sequence of Dscam in the crustacean Pacifastacus leniusculus (PlDscam), encodes 9(Ig)-4(FNIII)-(Ig)-2(FNIII)-TM and it has variable regions in the N-terminal half of Ig2 and Ig3 and the complete Ig7 and in the transmembrane domain. The cytoplasmic tail can generate multiple isoforms. PlDscam can generate more than 22,000 different unique isoforms. Bacteria and LPS injection enhanced the expression of PlDscam, but no response in expression occurred after a white spot syndrome virus (WSSV) infection or injection with peptidoglycans. Furthermore, PlDscam silencing did not have any effect on the replication of the WSSV. Bacterial specific isoforms of PlDscam were shown to have a specific binding property to each tested bacteria, E. coli or S. aureus. The bacteria specific isoforms of PlDscam were shown to be associated with bacterial clearance and phagocytosis in crayfish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.