ArticlePLoS genetics2011
Natural allelic variation defines a role for ATMYC1: trichome cell fate determination.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- From Model Plants toPlants (Basel, Switzerland) · 2026Review
- A Genome-Wide Association Screen for Genes Affecting Leaf Trichome Development and Epidermal Metal Accumulation in Arabidopsis.Plant, cell & environment · 2025Article
- Stem trichome polarity development in Gossypium hirsutum: insights into GhPRP gene regulation.Plant cell reports · 2025Article
- The bHLH transcription factor gene EGL3 accounts for the natural diversity in Arabidopsis fruit trichome pattern and morphology.Plant physiology · 2024Article
- The trichome pattern diversity of Cardamine shares genetic mechanisms with Arabidopsis but differs in environmental drivers.Plant physiology · 2024Article
- Genetic factors explaining anthocyanin pigmentation differences.BMC plant biology · 2024Article
- Identification and Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Comparative Transcriptomic Analysis Revealed the Suppression and Alternative Splicing of Kiwifruit (International journal of molecular sciences · 2023Article
- MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis.International journal of molecular sciences · 2023Review
- Differential environmental and genomic architectures shape the natural diversity for trichome patterning and morphology in different Arabidopsis organs.Plant, cell & environment · 2022Article
- Molecular Mechanisms of Plant Trichome Development.Frontiers in plant science · 2022Review
- Development of Molecular Markers for Predicting Radish (Plants (Basel, Switzerland) · 2021Article
- MYB transcription factors drive evolutionary innovations in Arabidopsis fruit trichome patterning.The Plant cell · 2021Article
- Regulatory Mechanisms of bHLH Transcription Factors in Plant Adaptive Responses to Various Abiotic Stresses.Frontiers in plant science · 2021Review
- Genetic determinism of prickles in rose.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Overexpression of bHLH95, a basic helix-loop-helix transcription factor family member, impacts trichome formation via regulating gibberellin biosynthesis in tomato.Journal of experimental botany · 2020Article
- Mapping QTLs for 15 morpho-metric traits inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- Comparative Transcriptomic Analysis to Identify the Genes Related to Delayed Gland Morphogenesis inGenes · 2020Article
- GLABRA2, A Common Regulator for Epidermal Cell Fate Determination and Anthocyanin Biosynthesis inInternational journal of molecular sciences · 2019Review
- The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves.Plants (Basel, Switzerland) · 2019Review
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3 authors.
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Abstract
The molecular nature of biological variation is not well understood. Indeed, many questions persist regarding the types of molecular changes and the classes of genes that underlie morphological variation within and among species. Here we have taken a candidate gene approach based on previous mapping results to identify the gene and ultimately a polymorphism that underlies a trichome density QTL in Arabidopsis thaliana. Our results show that natural allelic variation in the transcription factor ATMYC1 alters trichome density in A. thaliana; this is the first reported function for ATMYC1. Using site-directed mutagenesis and yeast two-hybrid experiments, we demonstrate that a single amino acid replacement in ATMYC1, discovered in four ecotypes, eliminates known protein-protein interactions in the trichome initiation pathway. Additionally, in a broad screen for molecular variation at ATMYC1, including 72 A. thaliana ecotypes, a high-frequency block of variation was detected that results in >10% amino acid replacement within one of the eight exons of the gene. This sequence variation harbors a strong signal of divergent selection but has no measurable effect on trichome density. Homologs of ATMYC1 are pleiotropic, however, so this block of variation may be the result of natural selection having acted on another trait, while maintaining the trichome density role of the gene. These results show that ATMYC1 is an important source of variation for epidermal traits in A. thaliana and indicate that the transcription factors that make up the TTG1 genetic pathway generally may be important sources of epidermal variation in plants.
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