ArticlePloS one2011
The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes?
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 46 citations in OpenAlex.
- The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2024Article
- The tubulin code specializes neuronal cilia for extracellular vesicle release.Developmental neurobiology · 2021Review
- Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.PLoS genetics · 2020Article
- Establishing and regulating the composition of cilia for signal transduction.Nature reviews. Molecular cell biology · 2019Review
- The sensory amphidial structures of Caenorhabditis elegans are involved in macrocyclic lactone uptake and anthelmintic resistance.International journal for parasitology · 2018Article
- CHCA-1 is a copper-regulated CTR1 homolog required for normal development, copper accumulation, and copper-sensing behavior inThe Journal of biological chemistry · 2018Article
- Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery.The FEBS journal · 2017Review
- Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia.Nature communications · 2017Article
- The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.Scientific reports · 2016Article
- The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas.Molecular biology of the cell · 2016Article
- Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella.Journal of cell science · 2016Article
- IFT-Cargo Interactions and Protein Transport in Cilia.Trends in biochemical sciences · 2015Review
- Dynein and intraflagellar transport.Experimental cell research · 2015Review
- Somatic CRISPR-Cas9-induced mutations reveal roles of embryonically essential dynein chains in Caenorhabditis elegans cilia.The Journal of cell biology · 2015Article
- The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.Journal of cell science · 2015Article
- The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions.Molecular biology of the cell · 2014Article
- The roles of evolutionarily conserved functional modules in cilia-related trafficking.Nature cell biology · 2013Review
- Protein sorting, targeting and trafficking in photoreceptor cells.Progress in retinal and eye research · 2013Review
- WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia.Molecular biology of the cell · 2013Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We analyzed the relatively poorly understood IFT-dynein (class DYNC2)-driven retrograde IFT pathway in C. elegans cilia, which yielded results that are surprising in the context of current models of IFT. Assays of C. elegans dynein gene expression and intraflagellar transport (IFT) suggest that conventional IFT-dynein contains essential heavy (CHE-3), light-intermediate (XBX-1), plus three light polypeptide chains that participate in IFT, but no "essential" intermediate chain. IFT assays of XBX-1::YFP suggest that IFT-dynein is transported as cargo to the distal tip of the cilium by kinesin-2 motors, but independent of the IFT-particle/BBSome complexes. Finally, we were surprised to find that the subset of cilia present on the OLQ (outer labial quadrant) neurons assemble independently of conventional "CHE-3" IFT-dynein, implying that there is a second IFT-dynein acting in these cilia. We have found a novel gene encoding a dynein heavy chain, DHC-3, and two light chains, in OLQ neurons, which could constitute an IFT-dynein complex in OLQ neuronal cilia. Our results underscore several surprising features of retrograde IFT that require clarification.
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