ArticlePloS one2011
Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Insights into the Gene Expression Profile of Classical Hodgkin Lymphoma: A Study towards Discovery of Novel Therapeutic Targets.Molecules (Basel, Switzerland) · 2024Article
- Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p.Oncoimmunology · 2023Article
- HIV and Hodgkin Lymphoma Survival: A Prospective Study in Botswana.JCO global oncology · 2022Article
- A combined antibody and DNA assay for EBV infection in children.Frontiers in pediatrics · 2022Article
- Novel approach to identify putative Epstein-Barr-virus microRNAs regulating host cell genes with relevance in tumor biology and immunology.Oncoimmunology · 2022Article
- Review
- Prevalence of Epstein–Barr Virus Genotypes in Pakistani Lymphoma PatientsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Utility of minimally invasive thoracoscopy for assessment of residual mediastinal lymphoma.Surgery · 2018Article
- Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population.Scientific reports · 2018Article
- HLA Allele E*01:01 Is Associated with a Reduced Risk of EBV-Related Classical Hodgkin Lymphoma Independently of HLA-A*01/*02.PloS one · 2015Article
- Clinical features and treatment outcomes of Hodgkin's lymphoma in Hong Kong Chinese.Archives of medical science : AMS · 2014Article
- Hodgkin lymphoma incidence in California Hispanics: influence of nativity and tumor Epstein-Barr virus.Cancer causes & control : CCC · 2014Article
- Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010.Infectious agents and cancer · 2014Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population. METHODOLOGY/PRINCIPAL
findings157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV- encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (<20 y). The median age of the Chinese patients was 9 years younger than that of the Dutch patients (28 y vs. 37 y). In addition, the age distribution between the two populations was strikingly different in both the EBV+ subgroups (p<0.001) and the EBV- subgroups (p = 0.01). The mixed cellularity subtype was almost 3x more frequent amongst the Chinese (p<0.001). CONCLUSION/SIGNIFICANCE: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV- nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.
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