ArticlePloS one2011
Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Striking the right balance with type I interferon signalling in cancer.Nature reviews. Cancer · 2026Review
- Respiratory virus immune response in the aged host.Immunity & ageing : I & A · 2026Review
- Functional genomics of inflamm-aging and immunosenescence.Briefings in functional genomics · 2022Review
- Review
- I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People.Frontiers in immunology · 2020Review
- Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals.Frontiers in microbiology · 2020Review
- Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Alcohol, aging, and innate immunity.Journal of leukocyte biology · 2017Review
- Encephalitozoon intestinalis Inhibits Dendritic Cell Differentiation through an IL-6-Dependent Mechanism.Frontiers in cellular and infection microbiology · 2016Article
- Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.The Journal of clinical investigation · 2014Article
- Targets of immune regeneration in rheumatoid arthritis.Mayo Clinic proceedings · 2014Review
- Impact of aging on antigen presentation cell function of dendritic cells.Current opinion in immunology · 2013Review
- Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses.Experimental gerontology · 2013Article
- IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Integration of immunity with physical and cognitive function in definitions of successful aging.Aging and disease · 2012Article
- Burn injury triggered dysfunction in dendritic cell response to TLR9 activation and resulted in skewed T cell functions.PloS one · 2012Article
- CD8OncoimmunologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Age associated impairment of immune function results in inefficient vaccination, tumor surveillance and increased severity of infections. Several alterations in adaptive immunity have been observed and recent studies report age related declines in innate immune responses to opportunistic pathogens including Encephalitozoon cuniculi. We previously demonstrated that conventional dendritic cells (cDC) from 9-month-old animals exhibit sub-optimal response to E. cuniculi infection, suggesting that age associated immune senescence begins earlier than expected. We focused this study on how age affects plasmacytoid DC (pDC) function. More specifically how aged pDC affect cDC function as we observed that the latter are the predominant activators of CD8 T cells during this infection. Our present study demonstrates that pDC from middle-aged mice (12 months) suppress young (8 week old) cDC driven CD8 T cell priming against E. cuniculi infection. The suppressive effect of pDC from older mice decreased maturation of young cDC via cell contact. Aged mouse pDC exhibited higher expression of PD-L1 and blockade of their interaction with cDC via this molecule restored cDC maturation and T cell priming. Furthermore, the PD-L1 dependent suppression of cDC T cell priming was restricted to effector function of antigen-specific CD8 T cells not their expansion. To the best of our knowledge, the data presented here is the first report highlighting a cell contact dependent, PD-L1 regulated, age associated defect in a DC subpopulation that results in a sub-optimal immune response against E. cuniculi infection. These results have broad implications for design of immunotherapeutic approaches to enhance immunity for aging populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.