ArticlePloS one2011
The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Tuberculosis transmission from healthcare workers to patients and co-workers: a systematic literature review and meta-analysis.PloS one · 2015Pooled it
- Revisiting annual screening for latent tuberculosis infection in healthcare workers: a cost-effectiveness analysis.BMC medicine · 2017Article
- Map the gap: missing children with drug-resistant tuberculosis.Public health action · 2015Article
- Cough Aerosol Cultures of Mycobacterium tuberculosis: Insights on TST / IGRA Discordance and Transmission Dynamics.PloS one · 2015Article
- How should I interpret an interferon gamma release assay result for tuberculosis infection?Thorax · 2013Article
- High background rates of positive tuberculosis-specific interferon-γ release assays in a low prevalence region of UK: a surveillance study.BMC infectious diseases · 2012Article
- Observational study of QuantiFERON®-TB gold in-tube assay in tuberculosis contacts in a low incidence area.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.