ArticleInfection and drug resistance2008
New simple decontamination method improves microscopic detection and culture of mycobacteria in clinical practice.
Article in Infection and drug resistance, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Molecular identification and resistance-associated gene profiling of non-tuberculous mycobacteria isolated from bovine clinical samples.Molecular biology reports · 2026Article
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- Antimycobacterial Activity ofCells · 2023Article
- Evaluation of Xpert MTB/RIF Assay, MTB Culture and Line Probe Assay for the Detection of MDR Tuberculosis in AFB Smear Negative Specimens.Diseases (Basel, Switzerland) · 2022Article
- Evaluation of a novel sputum processing ReaSLR methodology for improving sensitivity of smear microscopy in clinical samples.Medical journal, Armed Forces India · 2022Article
- Th22 response induced by Mycobacterium tuberculosis strains is closely related to severity of pulmonary lesions and bacillary load in patients with multi-drug-resistant tuberculosis.Clinical and experimental immunology · 2021Review
- Evaluation of the performance of an in-house duplex PCR assay targeting the IS6110 and rpoB genes for tuberculosis diagnosis in Cameroon.BMC infectious diseases · 2020Article
- Evaluation of the Copan Myco-TB kit for the decontamination of respiratory samples for the detection of Mycobacteria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- A new diagnostic tool for rapid and accurate detection ofSaudi journal of biological sciences · 2018Article
- Genetic diversity of Mycobacterium avium complex strains isolated in Argentina by MIRU-VNTR.Epidemiology and infection · 2017Article
- Novel approach for improving sensitivity of microscopic detection of acid-fast bacilli (AFB) by use of the ReaSLR method.Journal of clinical microbiology · 2013Article
- AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain.Journal of bacteriology · 2011Article
- Containment of bioaerosol infection risk by the Xpert MTB/RIF assay and its applicability to point-of-care settings.Journal of clinical microbiology · 2010Article
- Drug susceptibility profiling of pulmonaryAnnals of thoracic medicineArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was carried out at Dr. Cetrángolo Hospital, Buenos Aires, Argentina. The objective was to compare two digestion-decontamination procedures: the N-acetyl-L-cysteine-sodium citrate-NaOH (NALC-NaOH) and a combination of 7% NaCl plus NaOH, the hypertonic saline-sodium hydroxide (HS-SH) method, in detection and recovery of mycobacteria. Microscopy detection rates before and after concentration of specimens by both methods, were also compared. The study had two phases. Phase I: comparison of the gold standard NALC-NaOH and HS-SH on paired samples involving respiratory clinical specimens by means of receiver operating characteristic curve analysis. Phase II: blinded, randomized trial to assess the performance of HS-SH versus NALC-NaOH in clinical practice. Phase I: Positive microscopy rate was significantly increased in around 2.2% after concentration in comparison to that of specimens without concentration. The calculated sensitivity values for microscopy detection increased between 15.2% (HS-SH: 73.5%) to 16.7% (NALC-NaOH: 75.0%) over those without concentration (58.3%). Phase II: similar diagnostic rates by microscopy and cultures were obtained by either HS-SH or NALC-NaOH. The clinical performances were also very similar. These results and the low cost of the HS-SH procedure indicate the possibility of its implementation in clinical laboratories with high burden of tuberculosis cases and low resources.
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